Evidence map›Paper›PMID 37259360›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line.

Naheed Akhter, Sidra Batool, Samreen Gul Khan, Nasir Rasool, Fozia Anjum, Azhar Rasul, Şevki Adem, Sadaf Mahmood, Aziz Ur Rehman, Mehr Un Nisa and 5 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 5 countries.

Naheed AkhterDepartment of Biochemistry, Faculty of Life Science, Government College University Faisalabad, Faisalabad 38000, Pakistan.
Sidra BatoolDepartment of Chemistry, Drug Design and Medicinal Chemistry Laboratory, Faculty of Physical Science, Government College University, Faisalabad 38000, Pakistan.
Samreen Gul KhanDepartment of Chemistry, Drug Design and Medicinal Chemistry Laboratory, Faculty of Physical Science, Government College University, Faisalabad 38000, Pakistan.
Nasir RasoolDepartment of Chemistry, Drug Design and Medicinal Chemistry Laboratory, Faculty of Physical Science, Government College University, Faisalabad 38000, Pakistan.
Fozia AnjumDepartment of Chemistry, Drug Design and Medicinal Chemistry Laboratory, Faculty of Physical Science, Government College University, Faisalabad 38000, Pakistan.
Azhar RasulDepartment of Zoology, Faculty of Life Sciences, Government College University Faisalabad, Faisalabad 38000, Pakistan.ORCID 0000-0001-9669-7364
Şevki AdemDepartment of Chemistry, Faculty of Sciences, Çankırı Karatekin University, 18100 Çankırı, Turkey.
Sadaf MahmoodDepartment of Chemistry, Drug Design and Medicinal Chemistry Laboratory, Faculty of Physical Science, Government College University, Faisalabad 38000, Pakistan.
Aziz Ur RehmanDepartment of Chemistry, Government College University, Lahore 54000, Pakistan.
Mehr Un NisaDepartment of Chemistry, University of Lahore, Lahore 40100, Pakistan.
Zainib RazzaqDepartment of Chemistry, Drug Design and Medicinal Chemistry Laboratory, Faculty of Physical Science, Government College University, Faisalabad 38000, Pakistan.
Jørn B ChristensenDepartment of Chemistry, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0002-7641-8302
Mohammed A S AbourehabDepartment of Pharmaceutics College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0003-1348-6567
Syed Adnan Ali ShahFaculty of Pharmacy, Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor D. E., Malaysia.ORCID 0000-0002-8142-5013
Syahrul ImranAtta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor D. E., Malaysia.ORCID 0000-0001-7802-7359
Government College University, Faisalabad · PKUniversiti Teknologi MARA · MYÇankırı Karatekin University · TRGovernment College University, Lahore · PKUmm al-Qura University · SAUniversity of Copenhagen · DKUniversity of Lahore · PK

Funding

Ministry of Higher Education FRGS/1/2019/STG05/UITM/02/9Universiti Teknologi MARA System 600-IRMI/FRGS 5/3 (424/2019).
6 · The paper itself

Abstract

Triazole-based acetamides serve as important scaffolds for various pharmacologically active drugs. In the present work, structural hybrids of 1,2,4-triazole and acetamides were furnished by chemically modifying 2-(4-isobutylphenyl) propanoic acid (

Indexed as

1,2,4-triazole2-(4-isobutylphenyl) propanoic acidacetamidesanti-cancerhepatocellular carcinomamolecular docking

Identifiers

PMID37259360
PMCPMC9964635
OpenAlexW4318482295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.