Evidence map›Paper›PMID 37259346›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [

Kelly Smart, Ming-Qiang Zheng, Daniel Holden, Zachary Felchner, Li Zhang, Yanjiang Han, Jim Ropchan, Richard E Carson, Neil Vasdev, Yiyun Huang

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Quantitative analysis of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Angewandte Chemie (International ed. in English) · 2026
    Article
  4. Evaluation of [ACS chemical neuroscience · 2025
    Article
  5. Article
  6. Article
  7. Radiosynthesis and evaluation of a novelAmerican journal of nuclear medicine and molecular imaging · 2024
    Article
  8. Development and Optimization ofACS pharmacology & translational science · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Kelly SmartBrain Health Imaging Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON M5T 1R8, Canada.ORCID 0000-0002-4775-6943
Ming-Qiang ZhengYale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.
Daniel HoldenYale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.
Zachary FelchnerYale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.
Li ZhangYale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.
Yanjiang HanYale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.
Jim RopchanYale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.
Richard E CarsonYale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.ORCID 0000-0002-9338-7966
Neil VasdevBrain Health Imaging Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON M5T 1R8, Canada.ORCID 0000-0002-2087-5125
Yiyun HuangYale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.ORCID 0000-0002-6757-3220
Yale Cancer Center · USCentre for Addiction and Mental Health · CA

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Radiochemistry CoreP30DA046345 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI MACH, ROBERT H · 2019 to 2023
$9.4M
Translation of tau-selective PET radiopharmaceuticals in Alzheimers patientsR01AG052414 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI PRICE, JULIE C, VASDEV, NEIL · 2018 to 2021
$2.7M
Neuro-PET Radiotracer Discovery for Imaging Glycogen Synthase Kinase-3R01AG054473 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI VASDEV, NEIL · 2017 to 2020
$1.7M
NCATS NIH HHS UL1 TR001863NIA NIH HHS R01AG052414NIA NIH HHS R01AG054473NIDA NIH HHS P30 DA046345
6 · The paper itself

Abstract

Glycogen synthase kinase 3 (GSK-3) is a potential therapeutic target for a range of neurodegenerative and psychiatric disorders. The goal of this work was to evaluate two leading GSK-3 positron emission tomography (PET) radioligands, [

Indexed as

glycogen synthase kinase 3non-human primatespositron emission tomographyradiopharmaceutical

Identifiers

PMID37259346
PMCPMC9959234
OpenAlexW4318475027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.