Evidence map›Paper›PMID 37259122›Full record

ArticleJournal of translational medicine2023

Causality of genetically determined metabolites and metabolic pathways on osteoarthritis: a two-sample mendelian randomization study.

Yifei Gu, Qianmei Jin, Jinquan Hu, Xinwei Wang, Wenchao Yu, Zhanchao Wang, Chen Wang, Yang Liu, Yu Chen, Wen Yuan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 5 pooled it
26.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yifei Gu *Department of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Qianmei Jin *Department of Rheumatology and Immunology, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Jinquan Hu *Department of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Xinwei WangDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Wenchao YuDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Zhanchao WangDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Chen WangDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Yang LiuDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China. liuyangspine@hotmail.com.
Yu ChenDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China. yugangg2003@163.com.
Wen YuanDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China. YWspine@126.com.ORCID 0000-0001-7328-1198
Shanghai Changzheng Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteoarthritis (OA) is one of the most prevalent musculoskeletal diseases and is the leading cause of pain and disability in the aged population. However, the underlying biological mechanism has not been fully understood. This study aims to reveal the causal effect of circulation metabolites on OA susceptibility.

methodsA two-sample Mendelian Randomization (MR) analysis was performed to estimate the causality of GDMs on OA. A genome-wide association study (GWAS) of 486 metabolites was used as the exposure, whereas 8 different OA phenotypes, including any-site OA (All OA), knee and/or hip OA (knee/hip OA), knee OA, hip OA, spine OA, finger and/or thumb OA (hand OA), finger OA, thumb OA, were set the outcomes. Inverse-variance weighted (IVW) was used for calculating causal estimates. Methods including weight mode, weight median, MR-egger, and MR-PRESSO were used for the sensitive analysis. Furthermore, metabolic pathway analysis was performed via the web-based Metaconflict 4.0. All statistical analyses were performed in R software.

resultsIn this MR analysis, a total of 235 causative associations between metabolites and different OA phenotypes were observed. After false discovery rate (FDR) correction and sensitive analysis, 9 robust causative associations between 7 metabolites (e.g., arginine, kynurenine, and isovalerylcarnitine) and 5 OA phenotypes were finally identified. Additionally, eleven significant metabolic pathways in 4 OA phenotypes were identified by metabolic pathway analysis.

conclusionThe finding of our study suggested that identified metabolites and metabolic pathways can be considered useful circulating metabolic biomarkers for OA screening and prevention in clinical practice, and can also serve as candidate molecules for future mechanism exploration and drug target selection.

Indexed as

Osteoarthritis, HipOsteoarthritis, KneeGenome-Wide Association StudyHumansMendelian Randomization AnalysisMetabolic Networks and PathwaysPolymorphism, Single NucleotideArginineGenetically determined metabolitesKynurenineMendelian randomizationOsteoarthritis

Identifiers

PMID37259122
PMCPMC10230782
OpenAlexW4378907795

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.