Evidence map›Paper›PMID 37259117›Full record

ArticleBMC musculoskeletal disorders2023

Early disc degeneration in radiotherapy-treated childhood brain tumor survivors.

Petra Grahn, Tiina Remes, Reetta Kivisaari, Maria H Suo-Palosaari, Pekka M Arikoski, Päivi K T Koskenkorva, Päivi M Lähteenmäki, Tuula R I Lönnqvist, Marja K Ojaniemi, Kirsti H Sirkiä and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 2 countries.

Petra GrahnDepartment of Pediatric Orthopedics and Traumatology, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 9, PL 281, 00029, Helsinki, Finland. petra.grahn@hus.fi.
Tiina RemesDepartment of Pediatrics and Adolescent Medicine, Oulu University Hospital, and Research Unit of Clinical Medicine, University of Oulu, Helsinki, Finland.
Reetta KivisaariDepartment of Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Maria H Suo-PalosaariDepartment of Diagnostic Radiology, Oulu University Hospital and Research Unit of Medical Imaging, Physics, and Technology Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Pekka M ArikoskiKuopio Pediatric Research Unit, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Päivi K T KoskenkorvaDepartment of Clinical Radiology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Päivi M LähteenmäkiDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital, Turku University, Turku, Finland.
Tuula R I LönnqvistDepartment of Child Neurology, New Children's Hospital, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Marja K OjaniemiDepartment of Pediatrics and Adolescent Medicine, Oulu University Hospital, and Research Unit of Clinical Medicine, University of Oulu, Helsinki, Finland.
Kirsti H SirkiäDepartment of Pediatrics and Adolescence, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Anna K SutelaDepartment of Clinical Radiology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Sanna-Maria Toiviainen-SaloDepartment of Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Heikki M J RantalaDepartment of Pediatrics and Adolescent Medicine, Oulu University Hospital, and Research Unit of Clinical Medicine, University of Oulu, Helsinki, Finland.
Arja H HarilaDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Jaakko NiinimäkiDepartment of Diagnostic Radiology, Oulu University Hospital and Research Unit of Medical Imaging, Physics, and Technology Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Jaro KarppinenMedical Research Center Oulu, Department of Physical and Rehabilitation Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland.
Matti AhonenDepartment of Pediatric Orthopedics and Traumatology, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 9, PL 281, 00029, Helsinki, Finland.
Oulu University Hospital · FIHelsinki University Hospital · FIUniversity of Helsinki · FIKuopio University Hospital · FIUniversity of Oulu · FITurku University Hospital · FIUniversity of Eastern Finland · FIUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildhood brain tumor (BT) survivors have an increased risk of treatment-related late effects, which can reduce health-related quality of life and increase morbidity. This study aimed to investigate lumbar disc degeneration in magnetic resonance imaging (MRI) in adult survivors of radiotherapy-treated childhood BT compared to age and sex-matched population controls.

methodsIn this cross-sectional comparative study, 127 survivors were identified from hospital registries. After a mean follow-up of 20.7 years (range 5-33.1), 67 survivors (mean age 28.4, range 16.2-43.5) were investigated with MRI and compared to 75 sex-matched population-based controls. Evaluated MRI phenotypes included Pfirrmann grading, , intervertebral disc protrusions, extrusions, and high-intensity-zone-lesions (HIZ). Groups were also compared for known risk factors of lumbar intervertebral disc (IVD) degeneration.

resultsChildhood BT survivors had higher Pfirrmann grades than controls at all lumbar levels (all p < 0.001). Lumbar disc protrusions at L4-5 (p = 0.02) and extrusions at L3-4 (p = 0.04), L4-5 (p = 0.004), and L5-S1 (p = 0.01) were significantly more common in the BT group compared to the control. The survivor cohort also had significantly more HIZ-lesons than the controls (n=13 and n=1, p=0.003). Age at diagnosis was associated with lower degree of IVD degeneration (p < 0.01). Blood pressure correlated with IVD degeneration (P < 0.05).

conclusionsSigns of early disc degeneration related to tumor treatment can be seen in the IVDs of survivors. Disc degeneration was more severe in children treated in adolescence.

Indexed as

Brain NeoplasmsIntervertebral DiscIntervertebral Disc DegenerationIntervertebral Disc DisplacementChildCross-Sectional StudiesHumansLumbar VertebraeMagnetic Resonance ImagingQuality of LifeChildhood brain tumor survivorDisc degenerationRadiotherapy

Identifiers

PMID37259117
PMCPMC10230806
OpenAlexW4378831402

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.