ArticleBMC infectious diseases2023
Utility of urinary presepsin in the diagnosis of pyelonephritis: a cross-sectional study.
Article in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Admission CRP as an Independent Predictor of Prolonged Length of Stay in Calculous Acute Pyelonephritis: A Comparative Evaluation With the HALP Score.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Plasma presepsin as a predictor of mortality in patients with UTI-related severe infection: a single-center retrospective study.BMC urology · 2025Article
- Acute T-Cell Rejection after Living-Donor Kidney Transplantation: Monitoring with Urinary Presepsin.Cureus · 2025Article
- Urinary presepsin can efficiently detect T-cell-mediated rejection in patients who have undergone kidney transplantation.Clinical and experimental nephrology · 2025Article
- Urinary presepsin is a novel biomarker capable of directly assessing monocyte/macrophage infiltration in kidney diseases.Scientific reports · 2024Article
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4 authors.
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Abstract
backgroundPresepsin is produced during the phagocytosis of bacteria by granulocytes. Presepsin increases at the site of infection; however, the significance of urinary presepsin in pyelonephritis is unknown. This study aimed to evaluate whether measuring urinary presepsin can distinguish between pyelonephritis and nonpyelonephritis.
methodsA cross-sectional study of patients with suspected pyelonephritis was conducted. Urinary presepsin at admission was compared between the pyelonephritis and nonpyelonephritis groups using the Mann-Whitney test. The predictive accuracy of urinary presepsin for diagnosing pyelonephritis was evaluated by the area under the receiver operating characteristics (ROC) analysis curve.
resultsA total of 35 eligible participants were included in the pyelonephritis group and 25 in the nonpyelonephritis group. The median urinary presepsin level was 2232.0 (interquartile range [IQR], 1029.0-3907.0) pg/mL in the pyelonephritis group and 1348.0 (IQR, 614.5-2304.8) pg/mL in the nonpyelonephritis group. Urinary presepsin concentrations were significantly higher in the pyelonephritis group than in the nonpyelonephritis group (P = 0.023). ROC analysis of urinary presepsin revealed a cutoff value of 3650 pg/mL to distinguish between the pyelonephritis and nonpyelonephritis groups. Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio for the diagnosis of pyelonephritis were 0.40 (95% confidence interval [CI], 0.24-0.58), 0.96 (95% CI, 0.79-1.00), 0.93 (95% CI, 0.68-1.00), 0.52 (95% CI, 0.37-0.68), 9.60 (95% CI, 1.35-68.23), and 0.62 (95% CI, 0.47-0.83), respectively.
conclusionsThe measurement of urinary presepsin is useful in differentiating pyelonephritis from other diseases.
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