Evidence map›Paper›PMID 37258954›Full record

SynthesisJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2023

Meta-analysis of the effectiveness of heparin in suppressing physiological myocardial FDG uptake in PET/CT.

Shan-Ho Chan, Cheng-Kai Huang, Dmytro Luzhbin, Po-Nien Hou, Yu-Ting Chang, Jay Wu

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Human cardiac metabolism.Cell metabolism · 2024
    Review
  6. Unveiling the hidden link: deciphering the interplay between plaque characteristics and nuclear myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Shan-Ho Chan *Department of Medical Imaging and Radiology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan.
Cheng-Kai Huang *Department of Medical Imaging and Radiology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan.
Dmytro LuzhbinInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Po-Nien HouDepartment of Nuclear Medicine, Chang-Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
Yu-Ting ChangDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, No.155, Sec.2, Linong Street, Taipei, 11221, Taiwan.
Jay WuDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, No.155, Sec.2, Linong Street, Taipei, 11221, Taiwan. jaywu@nycu.edu.tw.
National Yang Ming Chiao Tung University · TWChang Bing Show Chwan Memorial Hospital · TWCheng Ching Hospital · TWInstitute of Statistical Science, Academia Sinica · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe present meta-analysis aims to investigate the effectiveness of heparin administration in suppressing physiological myocardial

methodsPRISMA guidelines were used to interrogate the PubMed, Embase, Cochrane library, Web of Knowledge, and www.clinicaltrail.gov databases from the earliest records to March 2023. The final analysis included five randomized controlled trials (RCTs). Meta-analysis was conducted to compare the effectiveness of unfractionated heparin (UFH) administration versus non-UFH administration, and subgroup analysis based on fixed and variable fasting durations was conducted. Effect sizes were pooled using a random-effects model, and the pooled odds ratios (ORs) were calculated.

resultsFive eligible RCTs with a total of 910 patients (550 with heparin, 360 without heparin) were included. The forest plot analysis initially indicated no significant difference in the suppression of myocardial FDG uptake between the UFH and non-UFH groups (OR 2.279, 95% CI 0.593 to  8.755, p = 0.23), with a high degree of statistical heterogeneity (I

conclusionsAccording to the findings of our meta-analysis, we suggest that intravenous administration of UFH can be considered as a supplementary approach to suppress myocardial FDG uptake.

Indexed as

Fluorodeoxyglucose F18HeparinAdministration, IntravenousHumansMyocardiumPositron-Emission TomographyPositron Emission Tomography Computed TomographyRadiopharmaceuticalsFluorodeoxyglucose F18HeparinRadiopharmaceuticalsFDGmyocardial FDG uptakePET/CTunfractionated heparin

Identifiers

PMID37258954
OpenAlexW4378803030

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.