Evidence map›Paper›PMID 37258944›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2023

Copper-flavonoid family of complexes involved in alkaline phosphatase activation.

Gisela M Gaddi, Janetsi Y Caro-Ramírez, Juliana E Parente, Patricia A M Williams, Evelina G Ferrer

Abstract read
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In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gisela M GaddiCEQUINOR, CONICET-UNLP-Asoc. CICPBA, Faculty of Exact Sciences, National University of La Plata, Bv. 120 No 1465, 1900, La Plata, Argentina.
Janetsi Y Caro-RamírezCEQUINOR, CONICET-UNLP-Asoc. CICPBA, Faculty of Exact Sciences, National University of La Plata, Bv. 120 No 1465, 1900, La Plata, Argentina.
Juliana E ParenteCEQUINOR, CONICET-UNLP-Asoc. CICPBA, Faculty of Exact Sciences, National University of La Plata, Bv. 120 No 1465, 1900, La Plata, Argentina.
Patricia A M WilliamsCEQUINOR, CONICET-UNLP-Asoc. CICPBA, Faculty of Exact Sciences, National University of La Plata, Bv. 120 No 1465, 1900, La Plata, Argentina.
Evelina G FerrerCEQUINOR, CONICET-UNLP-Asoc. CICPBA, Faculty of Exact Sciences, National University of La Plata, Bv. 120 No 1465, 1900, La Plata, Argentina. evelina@quimica.unlp.edu.ar.
Universidad Nacional de La Plata · ARConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

Agencia Nacional de Promoción Científica y Tecnológica ANPCyT-PICT-2019-00945Consejo Nacional de Investigaciones Científicas y Técnicas CONICET-PIP1999-2021-2023Universidad Nacional de La Plata UNLP-X929
6 · The paper itself

Abstract

The flavonoid naringenin and a family of naringenin derivative Cu(II) complexes having phenanthroline-based second ligands were selected to study alkaline phosphatase activation. This enzyme plays a critical role in tissue formation, increasing the inorganic phosphate formation, favoring mineralization, and being essential to producing bone mineralization. The effects of those compounds on the function and structure of the enzyme were evaluated by kinetic measurements, fluorescence, FTIR, and UV-Vis spectroscopies. The results showed that naringenin did not affect alkaline phosphatase activity, having a value of the Michaelis-Menten-constant close to the enzyme (Km = 3.07 × 10

Indexed as

Coordination ComplexesCopperAlkaline PhosphataseColoring AgentsFlavonoidsPhenanthrolinesAlkaline PhosphataseColoring AgentsCoordination ComplexesCopperFlavonoidsPhenanthrolinesAlkaline phosphatase activityALP structure modificationsCopper(II) naringenin complexesFluorescence spectroscopyNaringenin

Identifiers

PMID37258944
OpenAlexW4378806560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.