Evidence map›Paper›PMID 37258943›Full record

Trial reportEuropean journal of nutrition2023

The effects of long-term almond consumption on whole-body insulin sensitivity, postprandial glucose responses, and 48 h continuous glucose concentrations in males and females with prediabetes: a randomized controlled trial.

Elske Gravesteijn, Ronald P Mensink, Jogchum Plat

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03419702 (Effects of Almond Consumption on Chronic Glucose Regulation, Vascular Function and Cognitive Performance), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03419702 nacompletednot on this map

Effects of Almond Consumption on Chronic Glucose Regulation, Vascular Function and Cognitive Performance: The AL-INCLUSIVE Trial

TypeinterventionalSponsorMaastricht University Medical CenterRan2018 to 2021Enrolled43ConditionsPreDiabetes, Impaired Glucose Tolerance, Impaired Fasting Glucose, Overweight and ObesityArmsAlmonds
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elske GravesteijnDepartment of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+ (MUMC+), P.O. Box 616, 6200 MD, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-0967-3618
Ronald P MensinkDepartment of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+ (MUMC+), P.O. Box 616, 6200 MD, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-8908-3580
Jogchum PlatDepartment of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+ (MUMC+), P.O. Box 616, 6200 MD, Maastricht, The Netherlands. j.plat@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0002-1570-9608

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFindings concerning the effects of almond consumption on glucose metabolism are inconsistent which might relate to body weight gain. The effects of long-term almond consumption on glucose metabolism are investigated in a free-living setting without detailed dietary instructions in males and females with overweight/obesity and prediabetes.

methodsForty-three participants volunteered in this randomized, cross-over trial with a 5-months control and intervention period and a 2-months wash-out. In the intervention period participants daily consumed 50 g whole almonds. At the end of both periods insulin sensitivity was assessed by a hyperinsulinemic euglycemic clamp, and postprandial glucose responses, and 48 h continuous glucose concentrations were measured.

resultsAlmond consumption significantly decreased insulin sensitivity (P = 0.002), and increased postprandial glucose concentrations (P = 0.019), as well as fasting insulin concentrations (P = 0.003) as compared to the control period. The AUCs for 24 h glucose concentrations were not significantly different between control and intervention (P = 0.066). Almond consumption also significantly increased BMI (P = 0.002), and waist circumference (P = 0.013), supported by the concurrent increased energy intake (P = 0.031). The effects on glucose metabolism could only partly be explained by the observed weight gain as the almond effect remained after correcting for BMI changes.

conclusionsIn participants with prediabetes, long-term almond consumption showed adverse effects on insulin sensitivity and glucose metabolism. As almonds seemed not to have fully replaced other food items, it might be necessary to provide more supporting guidelines on how to incorporate energy-dense nuts into healthy diets to prevent type 2 diabetes development. CLINICAL

trial registrationThis clinical trial was registered in February 2018 as NCT03419702.

Indexed as

Diabetes Mellitus, Type 2Insulin ResistancePrediabetic StatePrunus dulcisBlood GlucoseCross-Over StudiesFemaleGlucoseHumansInsulinMalePostprandial PeriodBlood GlucoseGlucoseInsulinAlmondsGlucose metabolismHuman interventionHyperinsulinemic euglycemic clampInsulin sensitivityPrediabetes

Identifiers

PMID37258943
PMCPMC10421771

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.