ArticleMethods in molecular biology (Clifton, N.J.)2023
Prediction of TAP Transport of Peptides with Variable Length Using TAPREG.
Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
CD8 T cells recognize short peptides, more frequently of nine residues, presented by class I major histocompatibility complex (MHC I) molecules in the cell surface of antigen-presenting cells. These epitope peptides are loaded onto MHC I molecules in the endoplasmic reticulum, where they are shuttled from the cytosol by the transporter associated with antigen processing (TAP) as such or as N-terminal extended precursors of up to 16 residues. In this chapter, we describe the use of TAPREG, a tool for predicting TAP binding affinity that has been enhanced to identify potential CD8 T cell epitope precursors transported by TAP. TAPREG is available for free public use at http://imed.med.ucm.es/Tools/tapreg/ .
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