Evidence map›Paper›PMID 37258910›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Manufacture of Mesoporous Silicon Microparticles (MSMPs) as Adjuvants for Vaccine Delivery.

Ana López-Gomez, Irene Real-Arévalo, Raúl Martín-Palma, Eduardo Martínez-Naves, Manuel Gómez Del Moral

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ana López-GomezSchool of Medicine, Department of Cell Biology, Complutense University of Madrid, Madrid, Spain.
Irene Real-ArévaloSchool of Medicine, Department of Cell Biology, Complutense University of Madrid, Madrid, Spain.
Raúl Martín-PalmaSchool of Science, Department of Applied Physics, Autonoma University of Madrid, Madrid, Spain.
Eduardo Martínez-NavesSchool of Medicine, Department of Immunology, Complutense University of Madrid, Madrid, Spain.
Manuel Gómez Del MoralSchool of Medicine, Department of Cell Biology, Complutense University of Madrid, Madrid, Spain. mgomezm@med.ucm.es.
Universidad Complutense de Madrid · ESUniversidad Autónoma de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of computational approaches has accelerated the identification of vaccine candidates like epitope peptides. However, epitope peptides are usually very poorly immunogenic and adequate platforms are required with adjuvant capacity to verity immunogenicity and antigenicity of vaccine subunits in vivo. Silicon microparticles are being developed as potential new adjuvants for vaccine delivery due to their physicochemical properties. This chapter explains the methodology to fabricate and functionalize mesoporous silicon microparticles (MSMPs) which can be loaded with antigens of different nature, such as viral peptides, proteins, or carbohydrates, and this strategy is particularly suitable for delivery of epitopes identified by computer.

Indexed as

SiliconVaccinesAdjuvants, ImmunologicAdjuvants, PharmaceuticDrug Delivery SystemsEpitopesPeptidesAdjuvants, ImmunologicAdjuvants, PharmaceuticEpitopesPeptidesSiliconVaccinesAdjuvantCarbohydratesFunctionalizationMesoporous silicon microparticlesPeptidesVaccine

Identifiers

PMID37258910
OpenAlexW4378801457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.