Evidence map›Paper›PMID 37258801›Full record

ArticleScience China. Life sciences2023

Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke.

Maoqi Chen, Zhiyuan Lu, Xiaoyan Li, Ya Zong, Qing Xie, Sheng Li, Ping Zhou

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In one paragraph

Article in Science China. Life sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Maoqi ChenSchool of Rehabilitation Science and Engineering, University of Health and Rehabilitation Sciences, Qingdao, 266071, China.
Zhiyuan LuSchool of Rehabilitation Science and Engineering, University of Health and Rehabilitation Sciences, Qingdao, 266071, China. zhiyuan.lu@uor.edu.cn.
Xiaoyan LiDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Ya ZongDepartment of Rehabilitation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Qing XieDepartment of Rehabilitation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Sheng LiDepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center, Houston, TX, 77030, USA.
Ping ZhouSchool of Rehabilitation Science and Engineering, University of Health and Rehabilitation Sciences, Qingdao, 266071, China.

Funding

High-Density surface EMG based CMAP scan for motor unit number estimationR21NS113716 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI BARKHAUS, PAUL E, LI, XIAOYAN · 2020 to 2020
$432k
NINDS NIH HHS R21 NS113716
6 · The paper itself

Abstract

This study presents a novel compound muscle action potential (CMAP) examination of motor unit changes in paretic muscle post stroke. CMAP scan of the first dorsal interosseous (FDI) muscle was performed bilaterally in 16 chronic stroke subjects. Various parameters were derived from the CMAP scan to examine paretic muscle changes, including CMAP amplitude, D50, step index (STEPIX) and amplitude index (AMPIX). A significant decrease in CMAP amplitude and STEPIX was observed in paretic muscles compared with contralateral muscles (CMAP amplitude: paretic (9.0±0.5) mV, contralateral (11.3±0.9) mV, P=0.024; STEPIX: paretic 101.2±7.6, contralateral 121.9±6.5, P=0.020). No significant difference in D50 and AMPIX was observed between the paretic and contralateral sides (P>0.05). The findings revealed complex paretic muscle changes including motor unit degeneration, muscle fiber denervation, reinnervation and atrophy, providing useful insights to help understand neuromuscular mechanisms associated with weakness and other functional deterioration post stroke. The CMAP scan experimental protocols and the applied processing methods are noninvasive, convenient, and automated, offering practical benefits for clinical application.

Indexed as

Muscle, SkeletalStrokeAction PotentialsElectromyographyHumanscompound muscle action potential (CMAP) scanfirst dorsal interosseous (FDI)motor unitmuscle weaknessstep index (STEPIX)stroke

Identifiers

PMID37258801
PMCPMC11057326

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.