Evidence map›Paper›PMID 37258751›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

In Vivo Tissue Lipid Uptake in Antisense Oligonucleotide (ASO)-Treated Mice.

Igor Aurrekoetxea, Beatriz Gomez-Santos, Maider Apodaka-Biguri, Mikel Ruiz de Gauna, Francisco Gonzalez-Romero, Xabier Buqué, Patricia Aspichueta

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Anti-obesity peptides from food: Production, evaluation, sources, and commercialization.Comprehensive reviews in food science and food safety · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Igor AurrekoetxeaFaculty of Medicine and Nursing, Department of Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Beatriz Gomez-SantosFaculty of Medicine and Nursing, Department of Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Maider Apodaka-BiguriFaculty of Medicine and Nursing, Department of Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Mikel Ruiz de GaunaFaculty of Medicine and Nursing, Department of Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Francisco Gonzalez-RomeroFaculty of Medicine and Nursing, Department of Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Xabier BuquéFaculty of Medicine and Nursing, Department of Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Patricia AspichuetaFaculty of Medicine and Nursing, Department of Physiology, University of the Basque Country UPV/EHU, Leioa, Spain. patricia.aspichueta@ehu.eus.
University of the Basque Country · ESBioCruces Health research Institute · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of obesity has increased to pandemic levels over the past years. Associated comorbidities linked with the accumulation of lipids in different tissues and blood are responsible for the high mortality in these patients. The increased dietary lipid uptake contributes to these metabolic diseases. Identifying which pathways might be dysregulated in these patients will contribute to find new therapeutic targets. Thus, here, a protocol to follow up the distribution of dietary lipids in blood and tissues is provided. For this, radiolabeled triglyceride in olive oil is administered by oral gavage. To ascertain more precisely the capacity of each tissue for fatty acid uptake, not considering the intestinal barrier, the intravenous (IV) administration of radiolabeled lipids is also described.

Indexed as

Dietary FatsOligonucleotides, AntisenseAnimalsFatty AcidsMiceMice, Inbred C57BLObesityTriglyceridesDietary FatsFatty AcidsOligonucleotides, AntisenseTriglyceridesLipidsMetabolismRadioactiveTissuesTriglycerides

Identifiers

PMID37258751
OpenAlexW4378879361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.