Evidence map›Paper›PMID 37258680›Full record

ArticleNature2023

Transfer learning enables predictions in network biology.

Christina V Theodoris, Ling Xiao, Anant Chopra, Mark D Chaffin, Zeina R Al Sayed, Matthew C Hill, Helene Mantineo, Elizabeth M Brydon, Zexian Zeng, X Shirley Liu and 1 more

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 605 papers.

0numbers the graph read from it
0cells of the map it votes in
605citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

605 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Latent causal diffusions for single-cell perturbation modeling.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. LLM4PDA: Augmenting piRNA-Disease Association Prediction with Large Language Models.Interdisciplinary sciences, computational life sciences · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Target discovery and drug design in the era of artificial intelligence.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Mapping Gene Expression to an Interpretable Semantic Space.bioRxiv : the preprint server for biology · 2026
    Article
  20. Article

545 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christina V TheodorisDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA. christina.theodoris@gladstone.ucsf.edu.ORCID http://orcid.org/0000-0003-1658-1447
Ling XiaoCardiovascular Disease Initiative and Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Anant ChopraPrecision Cardiology Laboratory, Bayer US LLC, Cambridge, MA, USA.
Mark D ChaffinCardiovascular Disease Initiative and Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1234-5562
Zeina R Al SayedCardiovascular Disease Initiative and Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Matthew C HillCardiovascular Disease Initiative and Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Helene MantineoCardiovascular Disease Initiative and Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Elizabeth M BrydonPrecision Cardiology Laboratory, Bayer US LLC, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6140-8005
Zexian ZengDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
X Shirley LiuDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
Patrick T EllinorCardiovascular Disease Initiative and Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ellinor@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-2067-0533

Funding

IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
TRAINING GRANT IN GENETICST32GM007748 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Anne O'Donnell-Luria, Louise Wilkins-Haug · 1985 to 2026
$12.0M
Genomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3M
Using Electrocardiogram Genetics to Inform Arrhythmia RiskR01HL157635 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS, MIRSHAHI, TOORAJ · 2022 to 2025
$2.9M
NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL157635NIGMS NIH HHS T32 GM007748
6 · The paper itself

Abstract

Mapping gene networks requires large amounts of transcriptomic data to learn the connections between genes, which impedes discoveries in settings with limited data, including rare diseases and diseases affecting clinically inaccessible tissues. Recently, transfer learning has revolutionized fields such as natural language understanding

Indexed as

BiologyMachine LearningNeural Networks, ComputerCardiomyopathiesChromatinDatasets as TopicHumansSingle-Cell Gene Expression AnalysisChromatin

Identifiers

PMID37258680
PMCPMC10949956

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.