Evidence map›Paper›PMID 37258679›Full record

ArticleNature2023

Axonemal structures reveal mechanoregulatory and disease mechanisms.

Travis Walton, Miao Gui, Simona Velkova, Mahmoud R Fassad, Robert A Hirst, Eric Haarman, Christopher O'Callaghan, Mathieu Bottier, Thomas Burgoyne, Hannah M Mitchison and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
23.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 154 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Preclinical human models of primary ciliary dyskinesia.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  13. Article
  14. Article
  15. Functional Diversity and Emerging Roles of Human NME/NDPK Group II Proteins.International journal of molecular sciences · 2026
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. A Compound Heterozygous Missense Variant in TheInternational journal of fertility & sterility · 2026
    Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 5 countries.

Travis Walton *Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6812-1579
Miao Gui *Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9113-8029
Simona VelkovaGenetics and Genomic Medicine Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Mahmoud R FassadGenetics and Genomic Medicine Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Robert A HirstCentre for PCD Diagnosis and Research, Department of Respiratory Sciences, University of Leicester, Leicester, UK.
Eric HaarmanDepartment of Pediatric Respiratory Medicine and Allergy, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Christopher O'CallaghanInfection, Immunity & Inflammation Department, NIHR GOSH BRC, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Mathieu BottierRoyal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID 0000-0002-3148-6491
Thomas BurgoyneRoyal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID 0000-0002-8428-720X
Hannah M MitchisonGenetics and Genomic Medicine Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Alan BrownDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. alan_brown@hms.harvard.edu.ORCID 0000-0002-0021-0476
University College London · GBHarvard University · USGuy's and St Thomas' NHS Foundation Trust · GBEmma Kinderziekenhuis · NLUniversity of Leicester · GB

Funding

Mechanoregulation of Ciliary MotilityR01GM141109 · NIGMS · HARVARD MEDICAL SCHOOL · PI BROWN, ALAN · 2021 to 2025
$2.1M
Structural characterization of single, double and triple-headed axonemal dyneinsR01GM143183 · NIGMS · HARVARD MEDICAL SCHOOL · PI BROWN, ALAN · 2022 to 2025
$1.4M
NIGMS NIH HHS R01 GM141109NIGMS NIH HHS R01 GM143183
6 · The paper itself

Abstract

Motile cilia and flagella beat rhythmically on the surface of cells to power the flow of fluid and to enable spermatozoa and unicellular eukaryotes to swim. In humans, defective ciliary motility can lead to male infertility and a congenital disorder called primary ciliary dyskinesia (PCD), in which impaired clearance of mucus by the cilia causes chronic respiratory infections

Indexed as

AxonemeCiliaCiliary Motility DisordersFlagellaMechanotransduction, CellularArtificial IntelligenceAxonemal DyneinsChlamydomonas reinhardtiiCryoelectron MicroscopyHumansMaleMicrotubulesMovementProtein ConformationAxonemal Dyneins

Identifiers

PMID37258679
PMCPMC10266980
OpenAlexW4378800731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.