ArticleNature2023
Engineered tRNAs suppress nonsense mutations in cells and in vivo.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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95citing papers in PubMed
18.6field-weighted citation impact, top 1% of its field
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Who cites it
95 citing papers in PubMed, 121 citations in OpenAlex.
- Article
- Therapeutic rescue of pathogenic asparaginyl-tRNA synthetase alleles.Molecular therapy. Nucleic acids · 2026Article
- Programmed repair of disease-causing UGA premature termination codons in mammalian brain.Nucleic acids research · 2026Article
- Engineered tRNA reduces vision loss in a mouse model of Leber congenital amaurosis.Signal transduction and targeted therapy · 2026Article
- Engineered suppressor tRNAs enable precise translational control of genetic circuits in E. coli.Nucleic acids research · 2026Article
- Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs.Nature chemical biology · 2026Article
- Glutamine codon-driven translational readthrough reveals context-dependent stop codon decoding fidelity.bioRxiv : the preprint server for biology · 2026Article
- The regulation, function and disease relevance of cytoplasmic tRNAs.Nature reviews. Molecular cell biology · 2026Review
- Thioester-Containing Ionizable Lipids with Enhanced Endosomal Escape and Biodegradability for mRNA and tRNA Delivery.Pharmaceutics · 2026Article
- Self-Assembling Short Peptide Carriers for Gene Delivery.International journal of molecular sciences · 2026Review
- tRNA modifications in cancer: from molecular mechanisms to clinical translation.Biomarker research · 2026Review
- Tetrahedral DNA nanostructure-delivered suppressor tRNA ameliorates nephropathy inNAR molecular medicine · 2026Article
- Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung.Nature materials · 2026Article
- Reconstitution of CFTR ubiquitination identifies lysine-420 as a regulator of cell surface residence and current.Biochemistry and biophysics reports · 2026Article
- The New Wave of Gene and Cell Therapies Across Diseases.Journal of clinical medicine · 2026Review
- Mistranslation from an endogenous tRNA variant in human pan-genome cell lines.Nucleic acids research · 2026Article
- Anticodon-edited transfer RNAs (ACE-tRNAs) encoded as therapeutic nonviral minimal DNA vectors.Nucleic acids research · 2026Article
- Mistranslating tRNA variants impact the proteome and phosphoproteome of Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2026Article
- AAV-delivered UGA suppressor tRNA for disease-agnostic in vivo gene therapy.Nature biotechnology · 2026Article
- Design andMaterials today. Bio · 2026Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 5 institutions in 2 countries.
Suki AlbersInstitute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.
Elizabeth C AllenArcturus Therapeutics, San Diego, CA, USA.
Nikhil BhartiInstitute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.ORCID 0000-0002-4068-0325
Marcos DavytInstitute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.ORCID 0000-0001-6230-3654
Disha JoshiDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.
Carlos G Perez-GarciaArcturus Therapeutics, San Diego, CA, USA.ORCID 0000-0003-1571-4850
Leonardo SantosInstitute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.ORCID 0000-0001-5650-8098
Rajesh MukthavaramArcturus Therapeutics, San Diego, CA, USA.
Miguel Angel Delgado-ToscanoInstitute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.ORCID 0000-0001-9128-1511
Brandon MolinaArcturus Therapeutics, San Diego, CA, USA.
Kristen KuakiniArcturus Therapeutics, San Diego, CA, USA.
Maher AlayyoubiArcturus Therapeutics, San Diego, CA, USA.
Kyoung-Joo Jenny ParkArcturus Therapeutics, San Diego, CA, USA.ORCID 0000-0002-9703-1975
Grishma AcharyaArcturus Therapeutics, San Diego, CA, USA.
Jose A GonzalezArcturus Therapeutics, San Diego, CA, USA.
Amit SagiArcturus Therapeutics, San Diego, CA, USA.
Susan E BirketPulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Guillermo J TearneyWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
Steven M RowePulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Candela ManfrediDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.
Jeong S HongDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.
Kiyoshi TachikawaArcturus Therapeutics, San Diego, CA, USA.
Priya KarmaliArcturus Therapeutics, San Diego, CA, USA.
Daiki MatsudaArcturus Therapeutics, San Diego, CA, USA.
Eric J SorscherDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA. esorscher@emory.edu.ORCID 0000-0001-9341-3354
Pad ChivukulaArcturus Therapeutics, San Diego, CA, USA. pad@arcturusrx.com.ORCID 0000-0001-6017-2267
Zoya IgnatovaInstitute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany. zoya.ignatova@uni-hamburg.de.ORCID 0000-0002-9478-8825
Arcturus Therapeutics (United States) · USUniversität Hamburg · DEEmory University · USUniversity of Alabama at Birmingham · USMassachusetts General Hospital · US
Funding
UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Brian R. Davis · 2007 to 2026
$23.0MTranslational Program in CFTR-Related Airway DiseasesR35HL135816 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROWE, STEVEN MARK · 2017 to 2022
$6.3MRibosomal perturbation as a mechanism to prevent misfolding of CFTRR01HL136414 · NHLBI · EMORY UNIVERSITY · PI HARTMAN, JOHN L, SORSCHER, ERIC J · 2018 to 2025
$4.5MThe Role of Airway Mucus in Infection and InflammationR01HL153079 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BIRKET, SUSAN ELIZABETH · 2021 to 2025
$2.2MNHLBI NIH HHS R01 HL136414NHLBI NIH HHS R01 HL153079NHLBI NIH HHS R35 HL135816NIDDK NIH HHS P30 DK072482
Abstract
Nonsense mutations are the underlying cause of approximately 11% of all inherited genetic diseases
Indexed as
Codon, NonsenseCystic Fibrosis Transmembrane Conductance RegulatorRNA, TransferAmino AcidsAnimalsAnticodonBase PairingMiceNasal MucosaProtein BiosynthesisRibosome ProfilingAmino AcidsAnticodonCodon, NonsenseCystic Fibrosis Transmembrane Conductance RegulatorRNA, Transfer
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.