Evidence map›Paper›PMID 37258670›Full record

ArticleNature2023

In situ tumour arrays reveal early environmental control of cancer immunity.

Guadalupe Ortiz-Muñoz, Markus Brown, Catherine B Carbone, Ximo Pechuan-Jorge, Vincent Rouilly, Henrik Lindberg, Alex T Ritter, Gautham Raghupathi, Qianbo Sun, Tess Nicotra and 19 more

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Whole-body CD8Nature communications · 2025
    Trial
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Adhesion forces between macrophages and cancer cells promote early tumor development.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Guadalupe Ortiz-Muñoz *Genentech, South San Francisco, CA, USA.
Markus Brown *Genentech, South San Francisco, CA, USA.
Catherine B Carbone *Genentech, South San Francisco, CA, USA.ORCID 0000-0003-1610-4691
Ximo Pechuan-Jorge *Genentech, South San Francisco, CA, USA.
Vincent RouillyGenentech, South San Francisco, CA, USA.
Henrik LindbergGenentech, South San Francisco, CA, USA.
Alex T RitterGenentech, South San Francisco, CA, USA.
Gautham RaghupathiDepartment of Computer Science, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3606-5618
Qianbo SunGenentech, South San Francisco, CA, USA.
Tess NicotraGenentech, South San Francisco, CA, USA.ORCID 0009-0002-3938-3427
Shreya R MantriGenentech, South San Francisco, CA, USA.
Angela YangGenentech, South San Francisco, CA, USA.
Jonas DoerrGenentech, South San Francisco, CA, USA.
Deepti NagarkarGenentech, South San Francisco, CA, USA.
Spyros DarmanisGenentech, South San Francisco, CA, USA.ORCID 0000-0003-4002-8158
Benjamin HaleyGenentech, South San Francisco, CA, USA.
Sanjeev MariathasanGenentech, South San Francisco, CA, USA.
Yulei WangGenentech, South San Francisco, CA, USA.ORCID 0000-0002-9057-9786
Carlos Gomez-RocaIUCT, Institut Universitaire du Cancer de Toulouse, Toulouse, France.
Carlos Eduardo de AndreaDepartment of Pathology, Clínica Universidad de Navarra, Pamplona, Spain.
David SpigelSarah Cannon Research Institute, Nashville, TN, USA.
Thomas WuGenentech, South San Francisco, CA, USA.ORCID 0000-0003-4505-4531
Lelia DelamarreGenentech, South San Francisco, CA, USA.
Johannes SchönebergDepartment of Pharmacology, UCSD, San Diego, CA, USA.ORCID 0000-0001-7083-1828
Zora ModrusanGenentech, South San Francisco, CA, USA.
Richard PriceGenentech, South San Francisco, CA, USA.
Shannon J TurleyGenentech, South San Francisco, CA, USA.
Ira MellmanGenentech, South San Francisco, CA, USA.
Christine MoussionGenentech, South San Francisco, CA, USA. moussion.christine@gene.com.ORCID 0000-0002-1641-4094

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune phenotype of a tumour is a key predictor of its response to immunotherapy

Indexed as

NeoplasmsT-LymphocytesTumor MicroenvironmentFibroblastsHumansImmune Checkpoint InhibitorsImmunotherapyMonocytesPhenotypeImmune Checkpoint Inhibitors

Identifiers

PMID37258670
PMCPMC10284705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.