ArticleNature2023
Deterministic evolution and stringent selection during preneoplasia.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
17.5field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 73 citations in OpenAlex.
- Unraveling the lexicon of complex mutational phenomena in human cancers.Nature cancer · 2026Review
- Targeting the YAP-BST2 Axis Overcomes Intrinsic Anti-PD-1 Resistance in Metastatic Gastric Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reframing early gastric carcinogenesis through lineage, niche, and evolution.Cancer metastasis reviews · 2026Review
- Harnessing human tumor organoids for cancer modeling and precision therapy.Protein & cell · 2026Review
- Gastric Cancer Organoids: Mechanistic Insights, Drug Discovery, and Translational Advances in Precision Medicine.Journal of gastric cancer · 2026Review
- Charting single-cell lineages with synthetic and natural barcodes.Nature reviews. Genetics · 2026Review
- Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer.Molecular oncology · 2026Review
- Telomere Crisis Shapes Cancer Evolution.Cold Spring Harbor perspectives in biology · 2026Review
- The application of experimental models for the drug discovery for digestive tumors.Molecular cancer · 2026Review
- Strength through diversity: how cancers thrive when clones cooperate.Molecular oncology · 2026Review
- Article
- Single-cell atlas of gastric cancer reveals malignant epithelial evolution and regulatory reprogramming of the tumor microenvironment.PloS one · 2026Article
- Organoids glimpse: the nexus for diverse tumor heterogeneity.Frontiers in cell and developmental biology · 2026Review
- Integrated analysis of isorhamnetin-associated targets in chronic pancreatitis and pancreatic cancer: immune-infiltration associations and antitumor effects in pancreatic cancer cells.Frontiers in immunology · 2026Article
- Comprehensive characterization of SLC41A3 identifies it as an immune-related prognostic biomarker and therapeutic target in hepatocellular carcinoma.Frontiers in immunology · 2026Article
- Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects.MedComm · 2026Review
- The Double-Edged Sword of Genomic DNA Methylation: Orchestrating Gastric Carcinogenesis and Shaping Precision Oncology.Oncology research · 2026Review
- ALFA-K: Local adaptive mapping of karyotype fitness landscapes.Nature communications · 2025Article
- Deciphering precursor cell dynamics in esophageal preneoplasia via genetic barcoding and single-cell transcriptomics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 5 institutions in 3 countries.
Kasper Karlsson *Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Moritz J Przybilla *Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5645-9492
Eran KotlerDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-1463-7462
Aziz KhanStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6459-6224
Hang XuDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Kremena KaragyozovaStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Alexandra SockellDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Wing H WongStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Katherine LiuStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-9616-9403
Amanda MahDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Yuan-Hung LoDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Bingxin LuDepartment of Cell and Developmental Biology, University College London, London, UK.ORCID 0000-0002-0606-5150
Kathleen E HoulahanDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Zhicheng MaStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Carlos J SuarezDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Chris P BarnesDepartment of Cell and Developmental Biology, University College London, London, UK.ORCID 0000-0002-9459-1395
Calvin J KuoDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-7427-5985
Christina CurtisDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA. cncurtis@stanford.edu.ORCID 0000-0003-0166-3802
Stanford University · USUniversity College London · GBChan Zuckerberg Initiative (United States) · USScience for Life Laboratory · SEWellcome Sanger Institute · GB
Funding
Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4MRegulation of actively proliferating and quiescent intestinal stem cellsU01DK085527 · NIDDK · STANFORD UNIVERSITY · PI KUO, CALVIN J · 2009 to 2023
$6.9MForecasting tumor evolution: can the past reveal the future?DP1CA238296 · NCI · STANFORD UNIVERSITY · PI CURTIS, CHRISTINA N · 2018 to 2022
$5.5MOrganoid-based Discovery of Oncogenic Drivers and Treatment Resistance MechanismsU01CA217851 · NCI · STANFORD UNIVERSITY · PI CURTIS, CHRISTINA N, JI, HANLEE P · 2017 to 2021
$4.7MFunctional characterization of novel oncogenic loci driving progression and immune response in gastrointestinal cancerR00CA263014 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LO, YUAN-HUNG · 2023 to 2025
$747kTRANSCRIPTION FACTORS IN INTESTINAL DIFFERENTIATION AND CANCERK00CA212433 · NCI · STANFORD UNIVERSITY · PI LO, YUAN-HUNG · 2017 to 2020
$345kFunctional characterization of novel oncogenic loci driving progression and immune response in gastrointestinal cancerK99CA263014 · NCI · STANFORD UNIVERSITY · PI LO, YUAN-HUNG · 2021 to 2022
$343kNCI NIH HHS DP1 CA238296NCI NIH HHS K00 CA212433NCI NIH HHS K99 CA263014NCI NIH HHS P30 CA124435NCI NIH HHS R00 CA263014NCI NIH HHS U01 CA217851NIDDK NIH HHS U01 DK085527
Abstract
The earliest events during human tumour initiation, although poorly characterized, may hold clues to malignancy detection and prevention
Indexed as
Cell Transformation, NeoplasticClonal EvolutionPrecancerous ConditionsSelection, GeneticStomach NeoplasmsAneuploidyCell LineageDisease ProgressionDNA Copy Number VariationsGenomic InstabilityHumansMutationOrganoidsSingle-Cell AnalysisTumor Suppressor Protein p53TP53 protein, humanTumor Suppressor Protein p53
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.