Evidence map›Paper›PMID 37258638›Full record

ArticleAmino acids2023

The first evidence of biological activity for free Hypusine, an enigmatic amino acid discovered in the '70s.

Leticia Tamborlin, Karina Danielle Pereira, Dimitrius Santiago Passos Simões Fróes Guimarães, Leonardo Reis Silveira, Augusto Ducati Luchessi

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Amino acids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. The hypusine pathway inFrontiers in cellular and infection microbiology · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Leticia TamborlinLaboratory of Biotechnology, School of Applied Sciences, State University of Campinas (UNICAMP), Rua Pedro Zaccaria, 1300, Jardim Santa Luiza, Limeira, São Paulo, 13484-350, Brazil.ORCID http://orcid.org/0000-0003-1140-2841
Karina Danielle PereiraLaboratory of Biotechnology, School of Applied Sciences, State University of Campinas (UNICAMP), Rua Pedro Zaccaria, 1300, Jardim Santa Luiza, Limeira, São Paulo, 13484-350, Brazil.ORCID http://orcid.org/0000-0001-9424-6682
Dimitrius Santiago Passos Simões Fróes GuimarãesObesity and Comorbidities Research Center, Department of Structural and Functional Biology, State University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-3890-2910
Leonardo Reis SilveiraObesity and Comorbidities Research Center, Department of Structural and Functional Biology, State University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-9369-1047
Augusto Ducati LuchessiLaboratory of Biotechnology, School of Applied Sciences, State University of Campinas (UNICAMP), Rua Pedro Zaccaria, 1300, Jardim Santa Luiza, Limeira, São Paulo, 13484-350, Brazil. luchessi@unicamp.br.ORCID http://orcid.org/0000-0003-2080-3524
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/21914-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/24795-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/06951-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/17340-5
6 · The paper itself

Abstract

Hypusine amino acid [N

Indexed as

Amino AcidsLysineAnimalsCattleEukaryotic Translation Initiation Factor 5APeptide Initiation FactorsProtein Processing, Post-TranslationalRatsTemozolomideAmino AcidsEukaryotic Translation Initiation Factor 5AhypusineLysine(N(epsilon)-(4-amino-2-hydroxybutyl)-lysine)Peptide Initiation FactorsTemozolomideCell proliferationeIF5AHypusineOxidative metabolismPost-translational modificationProtein synthesis

Identifiers

PMID37258638
OpenAlexW4378953564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.