ArticleScientific reports2023
The impact of TLR2 and aging on the humoral immune response to Staphylococcus aureus bacteremia in mice.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 11 citations in OpenAlex.
- Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions.BMC medicine · 2026Review
- Enhanced immunogenicity of Staphylococcus aureus IsdE vaccine with SeNPs and BCG adjuvants in mice.AMB Express · 2026Article
- Multiorgan transcriptomics in mice identifies immunoglobulin heavy constant mu (Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- CD209d/e are required for macrophage-mediated phagocytosis and activation during methicillin-resistant Staphylococcus aureus pulmonary host defense.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Rejuvenating the gut: young plasma therapy improves cell proliferation, IGF-I and IGF-IR expression, and immune defense in aged male rats jejunum.Biogerontology · 2025Article
- Immunoglobulin: unraveling its complex web in aging.Frontiers in immunology · 2025Review
- Bacterial and host interactions inFrontiers in microbiology · 2025Review
- Immune aging and infectious diseases.Chinese medical journal · 2024Review
- Effect of middle-age plasma therapy on ileum morphology, immune defense (IgA) and cell proliferation (Ki-67) of female aged rats.Histochemistry and cell biology · 2024Article
- Local Immune Activation and Age Impact on Humoral Immunity in Mice, with a Focus on IgG Sialylation.Vaccines · 2024Article
- Molecular mechanisms of Sepsis attacking the immune system and solid organs.Frontiers in medicine · 2024Review
- Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies.Frontiers in microbiology · 2024Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging alters immunoglobulin production, affecting the humoral immune response. Toll-like receptor 2 (TLR2) recognizes Staphylococcus aureus (S. aureus) which causes bacteremia with high mortality in the elderly. To understand how TLR2 and aging affect the humoral immune response in bacteremia, four groups of mice (wild type-young, wild type-old, TLR2
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.