ArticleScientific reports2023
Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Neutrophil to lymphocyte ratio in Alzheimer's disease: A systematic review and meta-analysis.PloS one · 2024Pooled it
- The association between Naples prognostic score and cognitive function in older adults: A cross-sectional study of NHANES 2011 to 2014.Medicine · 2026Article
- Peripheral blood inflammatory biomarkers and response to vagus nerve stimulation in pediatric drug-resistant epilepsy: A retrospective cohort study.European journal of pediatrics · 2026Article
- A combined neuronal extracellular vesicle-haematology panel for clinical stratification of Alzheimer's disease and dementia.Metabolic brain disease · 2026Article
- Neutrophil inflammation metrics are associated with the risk of future dementia in large data from NYU Langone Hospitals and the Veterans Health Administration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026Review
- HDL cholesterol indicates neurodegenerative vulnerability in dementia with lewy bodies.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Relationship between insomnia and cognitive function in elderly Chinese cerebral small vessel disease patients: mediating effect of neutrophil-to-lymphocyte ratio.Frontiers in psychiatry · 2026Article
- Association between the Naples Prognostic Score and cognitive function in older adults: validation in Alzheimer's disease and vascular dementia.Frontiers in nutrition · 2026Article
- Tracing neuroinflammation in neurodegeneration: insights from a scoping review on biofluid biomarkers.Brain communications · 2026Review
- An integrated CSF-serum biomarker model for predicting clinical progression in Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Elevated Serum IL-6/IL-10 Ratio as a Promising Diagnostic and Disease Grading Biomarker for Cerebral Small Vessel Disease.Journal of inflammation research · 2026Article
- Association of Peripheral Blood Neutrophil-Lymphocyte Ratio With Motor and Cognitive Function in Prodromal Parkinson's Disease.Brain and behavior · 2025Article
- The predictivity of hematological parameters and related inflammatory biomarkers of male subjects with chronic polysubstance use disorder.Brain, behavior, & immunity - health · 2025Article
- Peripheral inflammation's variable impact on cognitive and symptomatic outcomes in Parkinson's disease: a longitudinal and cross-sectional analysis.NPJ Parkinson's disease · 2025Article
- Neutrophil-to-Lymphocyte Ratio in the Alzheimer's Disease Continuum.International journal of molecular sciences · 2025Review
- Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival.Molecular psychiatry · 2025Article
- Associations between neutrophil-lymphocyte ratio and risk of cognitive impairment among Chinese older adults.BMC geriatrics · 2025Article
- Structural and functional brain correlates of the neutrophil- and monocyte-to-lymphocyte ratio in neuropsychiatric disorders.Brain, behavior, & immunity - health · 2025Article
- The role of peripheral innate immune cells in Alzheimer's disease progression.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Neuroinflammation is believed to be a key process in Alzheimer's disease (AD) pathogenesis. Recently, the neutrophil-to-lymphocyte (NLR) and lymphocyte-to-monocyte ratios (LMR) have been proposed to be useful peripheral markers of inflammation. However, it is unclear how these inflammatory ratios relate to AD pathology, such as β-amyloid (Aβ) plaques and tau tangles. Using
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.