Evidence map›Paper›PMID 37258361›Full record

ArticleTrends in immunology2023

Signaling is the pathway to macrophage function.

Rachel A Gottschalk

Abstract read
In one paragraph

Article in Trends in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Innate Immune Memory is Stimulus Specific.bioRxiv : the preprint server for biology · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Rachel A GottschalkDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: rachel.gottschalk@pitt.edu.

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Linking steady-state cytokine signaling to alveolar macrophage function in homeostasis and lung infectionR01HL162658 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOTTSCHALK, RACHEL A · 2022 to 2025
$2.4M
Quantitative control of phosphorylation and mechanistic links to immune cell decisionsR35GM146896 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Rachel A Gottschalk · 2022 to 2026
$2.0M
NCI NIH HHS P30 CA047904NHLBI NIH HHS R01 HL162658NIGMS NIH HHS R35 GM146896
6 · The paper itself

Abstract

Tissue and inflammatory contexts are well appreciated to shape macrophage function to promote health or disease. However, there has been minimal progress towards understanding how these contexts modify signaling-to-transcription networks. Integration of mechanistic modeling and data-driven approaches will be crucial for investigating how cell state impacts macrophage decision-making.

Indexed as

Health PromotionSignal TransductionGene Regulatory NetworksHumansMacrophagescomputational modelingsignaling-to-transciptionsignal integrationsystems immunologytissue macrophage

Identifiers

PMID37258361
PMCPMC11460561

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.