ArticleParasites, hosts and diseases2023
Lophomonas blattarum-like organism in bronchoalveolar lavage from a pneumonia patient: current diagnostic scheme and polymerase chain reaction can lead to false-positive results.
Article in Parasites, hosts and diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Clinical and Radiological Characteristics of Patients with Lophomonas blattarum Detected in Bronchial Lavage: A Single-Center Experience.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Observational
- [From ICU to recovery: recurrent pneumonia due to Lophomonas blattarum].Revista medica del Instituto Mexicano del Seguro Social · 2026Article
- Insights into pulmonary lophomoniasis infection in a Bruton's disease patient; A case report study and literature review.IDCases · 2026Article
- First Report of the Pulmonary ParasiteAdvanced biomedical research · 2025Article
- First Molecular Evidence of Emerging Lophomonas Pathogen Among Patients Suspected of Having Pulmonary Tuberculosis in Mazandaran Province, Northern Iran.Acta parasitologica · 2024Article
- Imaging patterns of Lophomonas blattarum infection in the respiratory tract: a registry-based analysis.BMC infectious diseases · 2024Article
- Case series of complicated bronchopulmonary lophomoniasis. Differential diagnosis of tuberculosis?European clinical respiratory journal · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lophomonas blattarum is an anaerobic protozoan living in the intestine of cockroaches and house dust mites, with ultramicroscopic characteristics such as the presence of a parabasal body, axial filament, and absence of mitochondria. More than 200 cases of Lophomonas infection of the respiratory tract have been reported worldwide. However, the current diagnosis of such infection depends only on light microscopic morphological findings from respiratory secretions. In this study, we attempted to provide more robust evidence of protozoal infection in an immunocompromised patient with atypical pneumonia, positive for Lophomonas-like protozoal cell forms. A direct search of bronchoalveolar lavage fluid via polymerase chain reaction (PCR), transmission electron microscopy (TEM), and metagenomic next-generation sequencing did not prove the presence of protozoal infection. PCR results were not validated with sufficient rigor, while de novo assembly and taxonomic classification results did not confirm the presence of an unidentified pathogen. The TEM results implied that such protozoal forms in light microscopy are actually non-detached ciliated epithelial cells. After ruling out infectious causes, the patient's final diagnosis was drug-induced pneumonitis. These findings underscore the lack of validation in the previously utilized diagnostic methods, and more evidence in the presence of L. blattarum is required to further prove its pathogenicity.
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