Evidence map›Paper›PMID 37257564›Full record

Trial reportThe American journal of clinical nutrition2023

Prenatal and postnatal small-quantity lipid-based nutrient supplements and children's social-emotional difficulties at ages 9-11 y in Ghana: follow-up of a randomized controlled trial.

Elizabeth L Prado, Seth Adu-Afarwuah, Charles D Arnold, Ebenezer Adjetey, Benjamin Amponsah, Helena Bentil, Kathryn G Dewey, Amanda E Guyer, Adom Manu, Mavis Mensah and 4 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00970866 (Efficacy of Lipid-based Nutrient Supplements), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00970866 nacompletednot on this map

Efficacy of Lipid-based Nutrient Supplements (LNS) for Pregnant and Lactating Women and Their Infants

TypeinterventionalSponsorUniversity of California, DavisRan2009 to 2017Enrolled3,499ConditionsAnemia, Malnutrition, StuntingArmsIron and Folic Acid (IFA), Multiple Micronutrient (MMN) group, Lipid-based Nutrient Supplements (LNS) group
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Elizabeth L PradoInstitute for Global Nutrition, Department of Nutrition, University of California-Davis, Davis, CA, USA. Electronic address: elprado@ucdavis.edu.
Seth Adu-AfarwuahDepartment of Nutrition and Food Science, University of Ghana, Accra, Ghana.
Charles D ArnoldInstitute for Global Nutrition, Department of Nutrition, University of California-Davis, Davis, CA, USA.
Ebenezer AdjeteyDepartment of Nutrition and Food Science, University of Ghana, Accra, Ghana.
Benjamin AmponsahPsychology Department, University of Ghana, Accra, Ghana.
Helena BentilInstitute for Global Nutrition, Department of Nutrition, University of California-Davis, Davis, CA, USA.
Kathryn G DeweyInstitute for Global Nutrition, Department of Nutrition, University of California-Davis, Davis, CA, USA.
Amanda E GuyerCenter for Mind and Brain, University of California-Davis, Davis, CA, USA; Department of Human Ecology, University of California-Davis, Davis, CA, USA.
Adom ManuPublic Health, University of Ghana, Accra, Ghana.
Mavis MensahDepartment of Nutrition and Food Science, University of Ghana, Accra, Ghana.
Brietta M OaksDepartment of Nutrition and Food Sciences, University of Rhode Island, Kingston, RI, USA.
Maku OcanseyMcKing Consulting Corporation.
Xiuping TanInstitute for Global Nutrition, Department of Nutrition, University of California-Davis, Davis, CA, USA.
Paul D HastingsCenter for Mind and Brain, University of California-Davis, Davis, CA, USA; Department of Psychology, University of California-Davis, Davis, CA, USA.
University of California, Davis · USUniversity of Ghana · GHMcKing Consulting (United States) · USUniversity of Rhode Island · US

Funding

Neural mechanisms of protective effects of early nutrition on the development of social-emotional difficulties among children in GhanaR01HD099811 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Paul David Hastings · 2019 to 2026
$4.1M
NICHD NIH HHS R01 HD099811
6 · The paper itself

Abstract

backgroundProvision of small-quantity lipid-based nutrient supplements (SQ-LNSs) during early life improves growth and development. In the International Lipid-Based Nutrient Supplements DYAD-Ghana trial, prenatal and postnatal SQ-LNS reduced social-emotional difficulties at age 5 y, with greater effects among children in less-enriched home environments.

objectivesWe aimed to investigate the effect of prenatal and postnatal SQ-LNS on children's social-emotional problems at age 9-11 y.

methodsIn 2009-2011, 1320 pregnant women ≤20 wk gestation were randomly assigned to receive the following daily until 6 mo postpartum: 1) iron and folic acid until delivery, then placebo, 2) multiple micronutrients (MMNs), or 3) SQ-LNS (20 g/d). Children in group 3 received SQ-LNS from 6 to 18 mo. In 2021, we evaluated children's social-emotional outcomes with 6 assessment tools that used caregiver, teacher, and/or self-report to measure socioemotional difficulties, conduct problems, temperament, mood, anxiety, and emotion management.

resultsWe assessed outcomes in 966 children, comprising 79.4% of 1217 participants eligible for re-enrolment. No significant differences were found between the SQ-LNS and control (non-LNS groups combined) groups. Few children (<2%) experienced high parent-reported social-emotional difficulties at 9-11 y, in contrast to the high prevalence at age 5 in this cohort (25%). Among children in less-enriched early childhood home environments, the SQ-LNS group had 0.37 SD (-0.04 to 0.82) lower self-reported conduct problems than the control group (P-interaction = 0.047).

conclusionsOverall positive effects of SQ-LNS on social-emotional development previously found at age 5 y are not sustained to age 9-11 y; however, there is some evidence of positive effects among children in less-enriched environments. The lack of effects may be owing to low prevalence of social-emotional problems at preadolescence, resulting in little potential to benefit from early nutritional intervention at this age in this outcome domain. Follow-up during adolescence, when social-emotional problems more typically onset, may yield further insights. This trial was registered at clinicaltrials.gov as NCT00970866. https://clinicaltrials.gov/ct2/show/record/NCT00970866.

Indexed as

LipidsMicronutrientsAdolescentChildChild, PreschoolDietary SupplementsEmotionsFemaleFollow-Up StudiesGhanaHumansInfantPregnancyVitaminsLipidsMicronutrientsVitaminschild developmentGhanalipid-based nutrient supplementssocial–emotional developmentSQ-LNS

Identifiers

PMID37257564
PMCPMC10447494
OpenAlexW4378652271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.