Evidence map›Paper›PMID 37257452›Full record

ArticleMed (New York, N.Y.)2023

Single-cell transcriptomics reveal a hyperacute cytokine and immune checkpoint axis after cardiac arrest in patients with poor neurological outcome.

Tomoyoshi Tamura, Changde Cheng, Wenan Chen, Louis T Merriam, Humra Athar, Yaunghyun H Kim, Reshmi Manandhar, Muhammad Dawood Amir Sheikh, Mayra Pinilla-Vera, Jack Varon and 14 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Med (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 2 countries.

Tomoyoshi TamuraDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Changde ChengDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Wenan ChenCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Louis T MerriamDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Humra AtharDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Yaunghyun H KimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Reshmi ManandharDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Muhammad Dawood Amir SheikhDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Mayra Pinilla-VeraDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Jack VaronDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Peter C HouHarvard Medical School, Boston, MA 02115, USA; Division of Emergency Critical Care Medicine, Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Patrick R LawlerPeter Munk Cardiac Centre, Toronto General Hospital, Toronto, ON M5G 2N2, Canada; McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
William M OldhamDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Raghu R SeethalaHarvard Medical School, Boston, MA 02115, USA; Division of Emergency Critical Care Medicine, Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Yohannes TesfaigziDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Immunology of Cardiac Arrest Network (I-CAN)
Alexandra J WeissmanDepartment of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Rebecca M BaronDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Fumito IchinoseHarvard Medical School, Boston, MA 02115, USA; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Katherine M BergHarvard Medical School, Boston, MA 02115, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Erin A BohulaHarvard Medical School, Boston, MA 02115, USA; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
David A MorrowHarvard Medical School, Boston, MA 02115, USA; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Xiang ChenDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: xiang.chen@stjude.org.
Edy Y KimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: ekim11@bwh.harvard.edu.
Brigham and Women's Hospital · USSt. Jude Children's Research Hospital · USBeth Israel Deaconess Medical Center · USHarvard University · USMcGill University Health Centre · CAUniversity of Pittsburgh · US

Funding

Resolution of inflammation after cardiac arrestR01HL166487 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Edy Yong Kim · 2023 to 2026
$3.1M
The Role of Immature Tumor Subpopulations In Pediatric RhabdomyosarcomaR01CA262790 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Xiang Chen · 2022 to 2026
$2.1M
American Heart Association-American Stroke Association 15FTF25080205NCI NIH HHS R01 CA262790NHLBI NIH HHS R01 HL166487
6 · The paper itself

Abstract

backgroundMost patients hospitalized after cardiac arrest (CA) die because of neurological injury. The systemic inflammatory response after CA is associated with neurological injury and mortality but remains poorly defined.

methodsWe determine the innate immune network induced by clinical CA at single-cell resolution.

findingsImmune cell states diverge as early as 6 h post-CA between patients with good or poor neurological outcomes 30 days after CA. Nectin-2

conclusionsThe initial hours after CA may represent a window for therapeutic intervention in the resolution of inflammation via immune checkpoints.

fundingThis work was supported by funding from the American Heart Association, Brigham and Women's Hospital Department of Medicine, the Evergreen Innovation Fund, and the National Institutes of Health.

Indexed as

CytokinesTranscriptomeFemaleHumansInflammationKiller Cells, NaturalNectinsUnited StatesCytokinesNectinscardiac arrestcytokineimmune checkpointinflammationinterferon γmonocytenatural killer cellNectin-2peripheral blood mononuclear cellssingle-cell RNA sequencingTranslation to patients

Identifiers

PMID37257452
PMCPMC10524451
OpenAlexW4378952654

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.