Evidence map›Paper›PMID 37257400›Full record

ReviewCurrent opinion in microbiology2023

Metals and the cell surface of Cryptococcus neoformans.

Peng Xue, Guanggan Hu, Won Hee Jung, James W Kronstad

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Cryptococcal nutrient acquisition and pathogenesis: dining on the host.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  4. Transcription Factors Fzc9 and Pdr802 Regulate ATP Levels and Metabolism inInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Evidence for the role of Irk2 and Irk5 in ATP and metabolism regulation inFrontiers in cellular and infection microbiology · 2025
    Article
  7. Review
  8. Article
  9. Metals at the Host-Fungal Pathogen Battleground.Annual review of microbiology · 2024
    Review
  10. Review
  11. Article
  12. Connecting Cryptococcal Meningitis and Gut Microbiome.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Peng XueMichael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Guanggan HuMichael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Won Hee JungDepartment of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea.
James W KronstadMichael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada. Electronic address: kronstad@msl.ubc.ca.
University of British Columbia · CAChung-Ang University · KR

Funding

Comparative and functional genomics of C. neoformansR01AI053721 · NIAID · UNIVERSITY OF BRITISH COLUMBIA · PI KRONSTAD, JAMES W · 2003 to 2024
$5.4M
NIAID NIH HHS R01 AI053721
6 · The paper itself

Abstract

Recent studies in pathogenic yeasts reinforce our appreciation of the influence of metal homeostasis on the fungal cell surface. To illustrate this influence, we focus on recent studies on Cryptococcus neoformans, a fungal pathogen with a complex surface of a cell wall with embedded melanin and an attached polysaccharide capsule. Copper and iron are essential yet toxic metals, and current efforts demonstrate the importance of these metals for modulating the surface structure of C. neoformans cells in ways that contribute to fungal-host interactions during disease in vertebrate hosts. In this review, we briefly summarize mechanisms of acquisition and regulation for copper and iron, and then discuss recent insights into the connections between the metals and the cell surface.

Indexed as

CryptococcosisCryptococcus neoformansCopperFungal ProteinsIronCopperFungal ProteinsIron

Identifiers

PMID37257400
PMCPMC10513164
OpenAlexW4378701205

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.