Evaluating the quality consistency of antiviral oral liquid by high-performance liquid chromatography five-wavelength matched average fusion fingerprint combined with electrochemical fingerprint and ultraviolet spectral quantum fingerprint.

Jiajia Fan, Xinyi Wang, Qian Chang, Guoxiang Sun, Lili Lan

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Article in Journal of chromatography. A, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Jiajia FanSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.

Xinyi WangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.

Qian ChangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.

Guoxiang SunSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. Electronic address: gxswmwys@163.com.

Lili LanSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. Electronic address: lanlily1314@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antiviral oral liquid (AOL) was an antiviral drug currently in clinical trials against coronavirus disease 2019. This study aimed to improve its quality consistency evaluation method using fingerprint techniques from several aspects. First, the five-wavelength matched average fusion fingerprint (FMAFFP) for HPLC, electrochemical fingerprint (ECFP), and ultraviolet spectral quantum fingerprint (UVFP) was established for 22 samples, respectively. Their quality was then assessed using the average linear quantitative fingerprint method, and 22 samples were classified into eight quality grades. OPLS and PCA were then used further to explore the characteristic parameters of these three fingerprints. Five compounds were quantified simultaneously for the first time, and then the relationship between the average linear quantitative similarity (P

Indexed as

COVID-19Drugs, Chinese HerbalAntioxidantsAntiviral AgentsChromatography, High Pressure LiquidHumansAntioxidantsAntiviral AgentsDrugs, Chinese HerbalAntiviral oral liquidAverage linear quantitative fingerprint methodElectrochemical fingerprintFive-wavelength matched average fusion fingerprintUltraviolet spectral quantum fingerprint

Identifiers

PMID37257368

DOI10.1016/j.chroma.2023.464098

PMCPMC10204348

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.