Trial reportEuropean endodontic journal2023
The Effect of Final Irrigation Agitation Techniques on Postoperative Pain after Single Visit Root Canal Treatment of Symptomatic Irreversible Pulpitis: A Randomised Clinical Trial.
Trial report in European endodontic journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06711029 (Effect of Different Duration and Number of Passive Ultrasonic Irrigation Activation Cycles on Postoperative Pain in Teeth with Symptomatic Irreversible Pulpitis), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Different Duration and Number of Passive Ultrasonic Irrigation Activation Cycles on Postoperative Pain in Teeth with Symptomatic Irreversible Pulpitis: a Randomized Clinical Trial
Who cites it
11 citing papers in PubMed, 7 citations in OpenAlex.
- The effect of foraminal enlargement and irrigant activation technique on post-operative pain in necrotic teeth - a clinical study.BMC oral health · 2026Trial
- Postoperative pain following root canal treatment with XP-Endo Finisher-assisted irrigant activation: a double-blind randomized controlled trial.BMC oral health · 2025Trial
- The Impact of Different Final Irrigation Activation Techniques on Postoperative Pain in Single Rooted Mandibular Premolar Teeth: Randomised Clinical Trial.European endodontic journal · 2025Trial
- Determining the optimal irrigation activation or agitation techniques for postoperative pain control: A network meta-regression of clinical trials.The Japanese dental science review · 2026Review
- The recovery effect of dentin biomodifiers on microtensile bond strength and sealer-penetration depth of coronal and radicular dentin: an in vitro experimental study.Restorative dentistry & endodontics · 2026Article
- Effect of intracanal heating of sodium hypochlorite alone and in combination with ultrasonic activation on postoperative endodontic pain: A randomized clinical trial.Journal of conservative dentistry and endodontics · 2026Article
- Influence of Laser-Activated vs Ultrasonic Irrigation on Postoperative Pain Following Root Canal Treatment - A Systematic Review.Journal of pharmacy & bioallied sciences · 2026Article
- Comparative Analysis of Laser-Activated and Ultrasonic Irrigation on Postoperative Pain in Root Canal Therapy: A Systematic Review.Journal of pharmacy & bioallied sciences · 2025Review
- Influence of Ultrasonic Activation of Endodontic Irrigants on Microbial Reduction and Postoperative Pain: A Scoping Review of In Vivo Studies.Dentistry journal · 2025Review
- Characteristics and Effectiveness of XP-Endo Files and Systems: A Narrative Review.International journal of dentistry · 2024Review
- The effect of the irrigant activation protocol on postoperative pain in maxillary incisors with asymptomatic apical periodontitis: A three-arm randomized clinical trial.Clinical and experimental dental research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the degree of postoperative pain and rate of analgesic intake in patients with symptomatic irreversible pulpitis in mandibular first molar teeth at 6 h, 12 h, 24 h, 48 h, and 72 h after using different irrigation activation techniques in single-visit endodontic treatment.
methodsA total of 78 patients with symptomatic irreversible pulpitis with no signs of periapical pathology were randomly divided into 3 groups according to the final irrigation activation technique; Group XP-endo Finisher, Group Ultra X ultrasonic device, and Group side-vented needle. The teeth underwent standardised single-visit root canal treatment procedures using 2.5% sodium hypochlorite for irrigation. Each patient was given a chart to record postoperative pain at 6, 12, 24, 48 and 72 hours intervals. Ibuprofen, 400 mg tablets, was prescribed to be taken when the pain was unbearable. The incidence and number of analgesic tablets taken were recorded. Data were analysed using a Kruskal-Wallis test followed by a pairwise Mann-Whitney U test with Bonferroni correction for intergroup comparisons and Freidman's test followed by Dunn's post hoc test for intragroup comparisons.
resultsNo statistically significant difference was found between all groups regarding the incidence and intensity of pain at different time intervals (p>0.05). There was no significant difference in analgesic intake between different groups, with most cases in all groups not taking analgesics (p>0.05).
conclusionAdding XP-endo Finisher or passive ultrasonic irrigation to the final irrigation protocol in singlevisit endodontic treatment had no significant effect on postoperative pain or analgesic intake. (EEJ-2021-11-185).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.