ArticleScience advances2023
Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Multiple-context extinction strengthens fear suppression through hippocampal dopamine D2R-dependent memory updating.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Overlapping representations in the ventral hippocampus support rapid fear memory retrieval.Nature neuroscience · 2026Article
- A ventral hippocampus-basolateral amygdala circuit regulates the unconditioned stimulus retrieval-induced reconsolidation of remote fear memory.Journal of advanced research · 2026Article
- Neuropeptide Y co-opts neuronal ensembles for memory lability and stability.Nature neuroscience · 2026Article
- Dorsoventral hippocampus neural assemblies reactivate during sleep following an aversive experience.Nature neuroscience · 2026Article
- Predicting individual differences of fear and cognitive learning and extinction.Nature communications · 2026Article
- Intrinsic Functional Connectivity of Right Dorsolateral Prefrontal Cortex and Hippocampus Subregions Relates to Emotional and Sensory-Perceptual Properties of Intrusive Trauma Memories.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Integration of fear learning and fear expression across the dorsoventral axis of the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- Representational dynamics during extinction of fear memories in the human brain.Nature human behaviour · 2026Article
- Beta bursts mediate amygdala gating of hippocampal emotional encoding.bioRxiv : the preprint server for biology · 2025Article
- Synaptic signatures of perinatal cannabinoids: A systematic review of rodent hippocampal synaptic plasticity, learning, and memory.Drug and alcohol dependence reports · 2025Review
- How Fear Memory is Updated: From Reconsolidation to Extinction?Neuroscience bulletin · 2025Review
- Interplay between prenatal bisphenol exposure, postnatal maternal care, and offspring sex in predicting DNA methylation relevant to anxiety-like behavior in rats.Hormones and behavior · 2025Article
- Scaling of Ventral Hippocampal Activity during Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction.Molecular brain · 2025Article
- Post-conditioning sleep deprivation facilitates delay and trace fear memory extinction.Molecular brain · 2024Article
- Hippocampal contextualization of social rewards in mice.Nature communications · 2024Article
- Stimulation of an entorhinal-hippocampal extinction circuit facilitates fear extinction in a post-traumatic stress disorder model.The Journal of clinical investigation · 2024Article
- Distinct ventral hippocampal inhibitory microcircuits regulating anxiety and fear behaviors.Nature communications · 2024Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extinction memory retrieval is influenced by spatial contextual information that determines responding to conditioned stimuli (CS). However, it is poorly understood whether contextual representations are imbued with emotional values to support memory selection. Here, we performed activity-dependent engram tagging and in vivo single-unit electrophysiological recordings from the ventral hippocampus (vH) while optogenetically manipulating basolateral amygdala (BLA) inputs during the formation of cued fear extinction memory. During fear extinction when CS acquire safety properties, we found that CS-related activity in the vH reactivated during sleep consolidation and was strengthened upon memory retrieval. Moreover, fear extinction memory was facilitated when the extinction context exhibited precise coding of its affective zones. Last, these activity patterns along with the retrieval of the fear extinction memory were dependent on glutamatergic transmission from the BLA during extinction learning. Thus, fear extinction memory relies on the formation of contextual and stimulus safety representations in the vH instructed by the BLA.
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