Evidence map›Paper›PMID 37256493›Full record

ArticleJournal of endocrinological investigation2023

Serum HMGB1 levels are independently associated with glucose clamp-derived measures of insulin resistance in women with PCOS.

P Moghetti, C Catellani, C Sartori, M Migazzi, F Cirillo, M Villani, V Buia, B Righi, M Dauriz, T Fiers and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

P MoghettiUnit of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, P.le Stefani 1, 37126, Verona, Italy. paolo.moghetti@univr.it.ORCID http://orcid.org/0000-0003-3951-0297
C CatellaniDepartment of Mother and Child, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
C SartoriDepartment of Mother and Child, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
M MigazziUnit of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, P.le Stefani 1, 37126, Verona, Italy.
F CirilloDepartment of Mother and Child, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
M VillaniUnit of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, P.le Stefani 1, 37126, Verona, Italy.
V BuiaDepartment of Mother and Child, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
B RighiDepartment of Mother and Child, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
M DaurizUnit of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, P.le Stefani 1, 37126, Verona, Italy.
T FiersLaboratory for Hormonology and Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
F TosiUnit of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, P.le Stefani 1, 37126, Verona, Italy.
M E StreetDepartment of Mother and Child, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy. mariaelisabeth.street@unipr.it.ORCID http://orcid.org/0000-0001-8427-8971
University of Verona · ITAzienda Sanitaria Unità Locale di Reggio Emilia · ITGhent University Hospital · BEUniversity of Modena and Reggio Emilia · ITUniversity of Parma · IT

Funding

Ministero della Salute GR-2018-12367635
6 · The paper itself

Abstract

purposePCOS is associated with low grade inflammation which could play a role in insulin resistance and ovarian dysfunction. Preliminary findings suggested that serum levels of HMGB1, a cytokine involved in inflammation, might be altered in women with PCOS. Primary aim of this study was to assess whether HMGB1 serum concentrations are associated with PCOS and with the state of insulin resistance of these women.

methodsSixty women with PCOS, selected to have a similar proportion of subjects with altered or normal insulin sensitivity, and 29 healthy controls were studied. Serum HMGB1 levels were compared in subgroups of PCOS women and controls. In PCOS women, insulin sensitivity was assessed by the glucose clamp technique and HMGB1 was measured at baseline and after acute hyperinsulinemia.

resultsHMGB1 levels were similar in women with PCOS and controls and no elements used for diagnosing PCOS were associated with serum HMGB1. However, HMGB1 concentrations were higher in insulin-resistant vs insulin-sensitive PCOS women (p = 0.017), and inversely associated with insulin-induced total and non-oxidative glucose metabolism. In both subgroups of PCOS women, serum HMBG1 levels significantly increased after acute hyperinsulinemia.

conclusionsThese data suggest that HMGB1 levels are not associated with PCOS per se, but with insulin resistance. Further research should establish the underlying nature of this relationship, and whether this protein might play a role in the metabolic complications of PCOS.

Indexed as

HMGB1 ProteinHyperinsulinismInsulin ResistancePolycystic Ovary SyndromeFemaleGlucose Clamp TechniqueHumansInflammationInsulinHMGB1 ProteinInsulinHMGB1Hyperinsulinemic euglycemic clampInsulin resistancePCOS

Identifiers

PMID37256493
PMCPMC10632283
OpenAlexW4378782125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.