Evidence map›Paper›PMID 37256475›Full record

ArticleEuropean geriatric medicine2023

STOPP/START criteria for potentially inappropriate prescribing in older people: version 3.

Denis O'Mahony, Antonio Cherubini, Anna Renom Guiteras, Michael Denkinger, Jean-Baptiste Beuscart, Graziano Onder, Adalsteinn Gudmundsson, Alfonso J Cruz-Jentoft, Wilma Knol, Gülistan Bahat and 3 more

Erratum issued Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European geriatric medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07114094 (Development and Validation of a Deprescribing Tool Relevant to the Indian Context and Evaluation of Its Effectiveness in Reducing Inappropriate Polypharmacy in the Elderly), which is not on this map. Cited by 295 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
295citing papers in PubMed, 10 pooled it
85.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07114094 narecruitingnot on this mapstarted 2025, after this paper: background citation

Development and Validation of a Deprescribing Tool Relevant to the Indian Context and Evaluation of Its Effectiveness in Reducing Inappropriate Polypharmacy in the Elderly

TypeinterventionalSponsorIndian Council of Medical ResearchRan2025 to 2026Enrolled1,650ConditionsElderlyArmsDeprescribing Tool
3 · Its place in the literature

Who cites it

295 citing papers in PubMed, 10 syntheses or guidelines pooled it, 635 citations in OpenAlex.

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  9. Medication Use Quality and Safety in Older Adults: 2023 Update.Journal of the American Geriatrics Society · 2025
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235 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 12 institutions in 8 countries.

Denis O'MahonyDepartment of Medicine (Geriatric Medicine), School of Medicine, University College Cork, Cork, Ireland. denis.omahony@ucc.ie.ORCID 0000-0003-2236-5222
Antonio CherubiniGeriatria, Accettazione Geriatrica e Centro di Ricerca Per l'invecchiamento, IRCCS INRCA, Ancona, Italy.
Anna Renom GuiterasDepartment of Geriatric Medicine, Parc de Salut Mar, Barcelona, Spain.
Michael DenkingerInstitute for Geriatric Research, University of Ulm Geriatric Center, Alb-Donau, Ulm, Germany.
Jean-Baptiste BeuscartUniv. Lille, CHU Lille, ULR 2694 - METRICS: Évaluation des Technologies de Santé et des Pratiques Médicales, 59000, Lille, France.
Graziano OnderFondazione Policlinico Gemelli IRCCS and Università Cattolica del Sacro Cuore, Rome, Italy.
Adalsteinn GudmundssonLandspitali University Hospital, Reykjavik, Iceland.
Alfonso J Cruz-JentoftServicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.
Wilma KnolDepartment of Geriatric Medicine and Expertise Centre Pharmacotherapy in Old Persons (EPHOR), University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Gülistan BahatDivision of Geriatrics, Department of Internal Medicine, Istanbul Medical School, Istanbul University, Istanbul, Turkey.
Nathalie van der VeldeAmsterdam UMC Location University of Amsterdam, Internal Medicine, Section of Geriatric Medicine and Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Mirko PetrovicDepartment of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium.
Denis CurtinDepartment of Geriatric Medicine, Cork University Hospital, Wilton, Cork, Ireland.
Amsterdam University Medical Centers · NLCork University Hospital · IEInstituto Ramón y Cajal de Investigación Sanitaria · ESIstanbul University · TRIstituti di Ricovero e Cura a Carattere Scientifico · ITParc de Salut · ESReykjavík University · ISUniversità Cattolica del Sacro Cuore · ITUniversität Ulm · DEUniversité de Lille · FRUniversity College Cork · IEUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSTOPP/START is a physiological systems-based explicit set of criteria that attempts to define the clinically important prescribing problems relating to potentially inappropriate medications (PIMs-STOPP criteria) and potential prescribing omissions (PPOs-START criteria). The previous two versions of STOPP/START criteria were published in 2008 and 2015. The present study describes the revised and updated third version of the criteria.

methodsA detailed system-by-system review of the published literature from April 2014 to March 2022 was undertaken with the aim of including clinically important new explicit PIM and PPO criteria and removing any criteria considered to be no longer correct or outdated. A panel of 11 academic physicians with recognized expertise in geriatric pharmacotherapy from 8 European countries participated in a Delphi panel with the task of validating the draft criteria. The panel was presented with the draft new criteria using the SurveyMonkey® on-line platform in which panelists were asked to indicate their level of agreement on a five-point Likert scale.

resultsTwo hundred and four evidence-based draft criteria (one hundred and forty-five STOPP criteria, fifty-nine START criteria) were presented to panelists for assessment using the Delphi validation method. Over the course of four rounds of Delphi validation, the panel achieved consensus on 133 STOPP criteria and 57 START criteria, i.e., 190 STOPP/START criteria in total representing a 66.7% increase in the number of criteria compared to STOPP/START version 2 published in 2015.

conclusionA fully revised and updated version of STOPP/START criteria has been validated by a European expert panel using the Delphi consensus process.

Indexed as

Inappropriate PrescribingPotentially Inappropriate Medication ListAgedDrug PrescriptionsEuropeHumansPractice Patterns, Physicians'Adverse drug eventsMedication reviewMultimorbidityOlder peoplePolypharmacySTOPP/START criteria

Identifiers

PMID37256475
PMCPMC10447584
OpenAlexW4378783027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.