Evidence map›Paper›PMID 37256434›Full record

ArticleEJNMMI research2023

Inter-rater and intra-rater agreement of [

Daniel Johnathan Hughes, Gitasha Chand, Jessica Johnson, Damion Bailey, Kathryn Adamson, Vicky Goh, Gary J R Cook

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04436406 naunknown statusnot on this map

Measurement of PD-L1 Expression in Cancer to Monitor Treatment Response.

TypeinterventionalSponsorGuy's and St Thomas' NHS Foundation TrustRan2020 to 2024Enrolled30ConditionsNon-small Cell Lung Cancer, MelanomaArms[99mTc]-NM-01 SPECT/CT
NCT04992715 phase2unknown statusnot on this map

A Single-arm, Phase II Study to Evaluate PD-L1 Expression in Non-Small Cell Lung Cancer Using the 99mTc Labelled Anti-PD-L1 Single Domain Antibody (NM-01)

TypeinterventionalSponsorNanoMab Technology (UK) LimitedRan2022 to 2023Enrolled15ConditionsNon-Small Cell Lung CancerArms[99mTc]-NM01 SPECT/CT
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. PD-L1 imaging with [British journal of cancer · 2025
    Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Pharmaceutics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Daniel Johnathan HughesDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0003-2641-7632
Gitasha ChandDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0003-3565-3901
Jessica JohnsonDepartment of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Damion BaileyDepartment of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Kathryn AdamsonDepartment of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Vicky GohDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2321-8091
Gary J R CookDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. gary.cook@kcl.ac.uk.ORCID http://orcid.org/0000-0002-8732-8134
Guy's and St Thomas' NHS Foundation Trust · GBKing's College London · GBSt Thomas' Hospital · GB

Funding

Cancer Research UK C1519/A28682Wellcome Trust WT 203148/Z/16/Z
6 · The paper itself

Abstract

backgroundImmune checkpoint inhibitors, including those against programmed cell death protein-1 (PD-1) or its ligand (PD-L1), are routinely used to treat non-small cell lung cancer (NSCLC). PD-L1 is a validated prognostic and predictive immunohistochemical biomarker of anti-PD-1/PD-L1 therapy but displays temporospatial heterogeneity of expression. Non-invasive radiopharmaceutical techniques, including technetium-99m [

methodsParticipants (n = 14) with untreated advanced NSCLC underwent [

resultsThere was excellent inter-rater agreement of manual freehand SUV

conclusionQuantitative assessment of [ CLINICAL

trial registrationClinicalTrials.gov identifier no. NCT04436406 (registered 18th June 2020; available at https://clinicaltrials.gov/ct2/show/NCT04436406 ) and NCT04992715 (registered 5th August 2021; available at https://clinicaltrials.gov/ct2/show/NCT04992715 ).

Indexed as

ImmunotherapyNon-small cell lung cancerPD-L1Single-domain antibody (sdAb)SPECTTechnetium

Identifiers

PMID37256434
PMCPMC10232393
OpenAlexW4378781592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.