Evidence map›Paper›PMID 37256350›Full record

ArticleEuropean radiology2023

Diffusion tensor and kurtosis imaging reveal microstructural changes in the trigeminal nerves of patients with trigeminal neuralgia.

Xixun Qi, Yunyun He, Qiushi Wang, Sixie Ren, Haibo Yao, Wanyu Cao, Liming Guan

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Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Xixun QiDepartment of Radiology, First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Yunyun HeDepartment of Radiology, Jingzhou Central Hospital, Jingzhou, 434020, China.
Qiushi WangDepartment of Pain, First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Sixie RenDepartment of Radiology, Chengdu Second People's Hospital, Chengdu, 610000, China.
Haibo YaoMedical Records Office, Chengdu Women'S and Children'S Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Wanyu CaoDepartment of Radiology, First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Liming GuanDepartment of Radiology, First Affiliated Hospital of China Medical University, Shenyang, 110001, China. guanlm66@126.com.ORCID http://orcid.org/0000-0003-1828-1296
China Medical University · CNFirst Hospital of China Medical University · CNChengdu Second People's Hospital · CNJingzhou Central Hospital · CNUniversity of Electronic Science and Technology of China · CN

Funding

Department of Science and Technology of Liaoning Province 20180530018
6 · The paper itself

Abstract

objectivesTo evaluate the use of diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) for detection of microstructural changes in the trigeminal nerves of trigeminal neuralgia (TN) patients.

methodsForty TN patients and 40 healthy controls were examined using 3 T magnetic resonance imaging (MRI) to evaluate DTI and DKI parameters in trigeminal nerves. One-way ANOVA was used to test the differences in age, sex, and DTI and DKI parameters between the TN-affected sides, TN-unaffected sides, and controls. For parameters with inter-group differences, pairwise comparisons were performed. Then, the difference ratios (DRs) of the parameters with statistical differences were calculated and used for the receiver operating characteristic (ROC) analysis to assess their diagnostic performance. In addition, for the DTI and DKI parameter values with differences, we used pure DTI and DKI values to perform the ROC analysis.

resultsCompared to the unaffected sides and controls, the FA, MK, and Kr of the affected sides of TN patients were significantly reduced, while ADC was significantly increased (p < 0.05). The diagnostic efficiency of the FA DRs (AUC: 0.974; cutoff value: 0.038; sensitivity: 100%; specificity: 95.0%) was the highest among all DTI and DKI parameters. The DRs of FA and MK more efficiently diagnosed TN than pure FA and MK values.

conclusionsDTI and DKI allowed detection of microstructural changes in TN-affected trigeminal nerves. FA DR was the best independent predictor of microstructural changes in TN. CLINICAL RELEVANCE STATEMENT: Both DTI and DKI can be used for noninvasive quantitative evaluation of the changes in the microstructure of the cisternal segment of the cranial nerves in clinical practice. KEY POINTS: • Diffusion tensor imaging (DTI) can be used to evaluate the in vivo integrity of white matter and nerve fiber pathway. • Diffusion kurtosis imaging (DKI) has been shown to be considerable sensitive to microstructural changes. • DTI combined with DKI can comprehensively evaluate the status of the TN-affected trigeminal nerve.

Indexed as

Trigeminal NeuralgiaWhite MatterDiffusion Tensor ImagingHumansMagnetic Resonance ImagingTrigeminal NerveDiffusion magnetic resonance imagingMagnetic resonance imagingTrigeminal nerveTrigeminal neuralgia

Identifiers

PMID37256350
OpenAlexW4378772093

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.