ArticleFrontiers in immunology2023
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Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 13 citations in OpenAlex.
- Acute Kidney Injury-to-Chronic Kidney Disease Transition-Associated Macrophage Subtypes: Biological Functions and Intercellular Crosstalk.International journal of molecular sciences · 2026Review
- Tissue-Resident Macrophage in Inflammation and Cancer.MedComm · 2026Review
- Neutrophil depletion exacerbatesFood and waterborne parasitology · 2026Article
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- Macrophage Niche Reconstitution Reveals Dynamic Transcriptional and Communication Networks Renal Macrophage-Epithelial Communication.Research square · 2026Article
- Hemodynamics and matrix stiffness shape the pathogenicity of SPP1Frontiers in immunology · 2026Review
- CX3CR1 and CCR2: dynamic myeloid cell states across inflammatory diseases with implications for oral health and disease.Frontiers in immunology · 2026Review
- Macrophage polarization in ischemia-reperfusion injury: from molecular mechanisms to therapeutic strategies.Frontiers in immunology · 2026Review
- AMSC-EVs attenuate acute kidney injury through TXNIP-IKKα/NFκB signaling-mediated renal CX3CR1Stem cell research & therapy · 2025Article
- Renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.Journal of cell science · 2025Article
- Recruitment of pulmonary intravascular macrophages in SARS-CoV-2 infected hamsters.Cell and tissue research · 2025Article
- Tissue-resident macrophages and renal diseases: landscapes and treatment directions.Frontiers in immunology · 2025Review
- The multifaceted role of macrophages in kidney physiology and diseases.Frontiers in immunology · 2025Review
- Progesterone promotes CXCl2-dependent vaginal neutrophil killing by activating cervical resident macrophage-neutrophil crosstalk.JCI insight · 2024Article
- Kidney resident macrophages have distinct subsets and multifunctional roles.Matrix biology : journal of the International Society for Matrix Biology · 2024Article
- Homeostatic Functions of Tissue-Resident Macrophages and Their Role in Tissue Maintenance.Results and problems in cell differentiation · 2024Review
- Macrophage Depletion Protects Against Cisplatin-Induced Ototoxicity and Nephrotoxicity.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 4 institutions in 2 countries.
Alex YashchenkoDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Sarah J BlandDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Cheng J SongDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
Ummey Khalecha Bintha AhmedDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Rachel SharpDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Isabella G DarbyDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Audrey M CordovaDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Morgan E SmithDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Jeremie M LeverDepartment of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, United States.
Zhang LiDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
Ernald J AloriaDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
Shuja KhanDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Bibi MaryamDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Shanrun LiuDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, United States.
Michael R CrowleyDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, United States.
Kenneth L JonesDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Lauren A ZenewiczDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
James F GeorgeDepartment of Surgery, Division of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, AL, United States.
Michal MrugDepartment of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, United States.
David K CrossmanDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, United States.
Katharina HoppDepartment of Medicine, Division of Renal Diseases and Hypertension, Polycystic Kidney Disease Program, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Stavros StavrakisDepartment of Internal Medicine, Division of Cardiovascular Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Mary B HumphreyDepartment of Internal Medicine, Division of Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Florent GinhouxSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Singapore, Singapore.
Kurt A ZimmermanDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
University of Oklahoma Health Sciences Center · USUniversity of Alabama at Birmingham · USAgency for Science, Technology and Research · SGUniversity of Colorado Anschutz Medical Campus · US
Funding
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1MUAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3MVascular-macrophage crosstalk in GBM immunosuppressionP20GM134973 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Sree Deepthi Muthukrishnan · 2020 to 2026
$17.6MUAB Recessive PKD Research and Translational Core CenterP30DK074038 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 2005 to 2019
$16.6MIMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1MResearch BaseP30DK090868 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WATNICK, TERRY J · 2010 to 2019
$11.1MROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5MUAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Therapeutic Development and Screening ResourceU54DK126087 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Bradley K. Yoder · 2020 to 2026
$6.7MMechanisms of C3 effects in ARPKD pathogenesisR01DK097423 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MRUG, MICHAL · 2013 to 2017
$1.6MTargeting kidney resident macrophage niche filling to slow cystic kidney diseaseR01DK129255 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Kurt A Zimmerman · 2022 to 2026
$1.6MDefining the functional role of T-cells in Autosomal Dominant Polycystic Kidney Disease pathologyK01DK114164 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HOPP, KATHARINA · 2018 to 2022
$783kInvestigating CD4 T regulatory cells during rapid cystogenesisK01DK119375 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZIMMERMAN, KURT A · 2020 to 2023
$608kBLRD VA I01 BX002298BLRD VA I01 BX004232NIAID NIH HHS P30 AI027767NIAID NIH HHS T32 AI007051NIAMS NIH HHS P30 AR048311NIDDK NIH HHS K01 DK114164NIDDK NIH HHS K01 DK119375NIDDK NIH HHS P30 DK074038NIDDK NIH HHS P30 DK079337NIDDK NIH HHS P30 DK090868NIDDK NIH HHS R01 DK097423NIDDK NIH HHS R01 DK129255NIDDK NIH HHS U54 DK126087NIGMS NIH HHS P20 GM134973
Abstract
Kidney macrophages are comprised of both monocyte-derived and tissue resident populations; however, the heterogeneity of kidney macrophages and factors that regulate their heterogeneity are poorly understood. Herein, we performed single cell RNA sequencing (scRNAseq), fate mapping, and parabiosis to define the cellular heterogeneity of kidney macrophages in healthy mice. Our data indicate that healthy mouse kidneys contain four major subsets of monocytes and two major subsets of kidney resident macrophages (KRM) including a population with enriched
Indexed as
MacrophagesMonocytesAnimalsCX3C Chemokine Receptor 1Disease Models, AnimalKidneyMiceReceptors, ChemokineCX3C Chemokine Receptor 1Cx3cr1 protein, mouseReceptors, ChemokineCCR2CX3CR1cystic kidney diseasefate mappingkidney macrophagesmacrophage heterogeneityparabiosissingle cell RNA sequencing (scRNAseq)
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.