Evidence map›Paper›PMID 37255989›Full record

ArticleJournal of the Intensive Care Society2023

Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial.

Ellen Pauley, Thomas M Drake, David M Griffith, Louise Sigfrid, Nazir I Lone, Ewen M Harrison, J Kenneth Baillie, Janet T Scott, Timothy S Walsh, Malcolm G Semple and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the Intensive Care Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Ellen Pauley, Edinburgh, UKUniversity of Edinburgh Medical School.ORCID https://orcid.org/0000-0001-6994-9722
Thomas M DrakeCentre for Medical Informatics, The Usher Institute, , Edinburgh, UKUniversity of Edinburgh.
David M GriffithAnaesthesia, Critical Care and Pain Medicine, , Edinburgh, UKUniversity of Edinburgh.
Louise SigfridCentre for Tropical Medicine and Global Health, , Oxford, UKUniversity of Oxford.
Nazir I LoneAnaesthesia, Critical Care and Pain Medicine, , Edinburgh, UKUniversity of Edinburgh.ORCID https://orcid.org/0000-0003-2707-2779
Ewen M HarrisonCentre for Medical Informatics, The Usher Institute, , Edinburgh, UKUniversity of Edinburgh.
J Kenneth BaillieAnaesthesia, Critical Care and Pain Medicine, , Edinburgh, UKUniversity of Edinburgh.
Janet T Scott, Glasgow, UKMRC-University of Glasgow Centre for Virus Research.
Timothy S WalshAnaesthesia, Critical Care and Pain Medicine, , Edinburgh, UKUniversity of Edinburgh.
Malcolm G SempleNIHR Health Protection Unit in Emerging Infectious Diseases, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, , Liverpool, UKUniversity of Liverpool.
Annemarie B DochertyCentre for Medical Informatics, The Usher Institute, , Edinburgh, UKUniversity of Edinburgh.
ISARIC4C and RECOVER Investigators
University of Edinburgh · GBMRC University of Glasgow Centre for Virus Research · GBRoslin Institute · GBUniversity of Liverpool · GBUniversity of Oxford · GB

Funding

Medical Research Council MC_PC_19025Medical Research Council MC_PC_19026Medical Research Council MC_PC_19059Medical Research Council MC_UU_12014/8
6 · The paper itself

Abstract

Background: We aimed to compare the prevalence and severity of fatigue in survivors of Covid-19 versus non-Covid-19 critical illness, and to explore potential associations between baseline characteristics and worse recovery. Methods: We conducted a secondary analysis of two prospectively collected datasets. The population included was 92 patients who received invasive mechanical ventilation (IMV) with Covid-19, and 240 patients who received IMV with non-Covid-19 illness before the pandemic. Follow-up data were collected post-hospital discharge using self-reported questionnaires. The main outcome measures were self-reported fatigue severity and the prevalence of severe fatigue (severity >7/10) 3 and 12-months post-hospital discharge. Results: Covid-19 IMV-patients were significantly younger with less prior comorbidity, and more males, than pre-pandemic IMV-patients. At 3-months, the prevalence (38.9% [7/18] vs. 27.1% [51/188]) and severity (median 5.5/10 vs 5.0/10) of fatigue were similar between the Covid-19 and pre-pandemic populations, respectively. At 6-months, the prevalence (10.3% [3/29] vs. 32.5% [54/166]) and severity (median 2.0/10 vs. 5.7/10) of fatigue were less in the Covid-19 cohort. In the total sample of IMV-patients included (i.e. all Covid-19 and pre-pandemic patients), having Covid-19 was significantly associated with less severe fatigue (severity <7/10) after adjusting for age, sex and prior comorbidity (adjusted OR 0.35 (95%CI 0.15-0.76, Conclusion: Fatigue may be less severe after Covid-19 than after other critical illness.

Indexed as

COVID-19critical carecritical illnessintensive care unitsSARS-CoV-2

Identifiers

PMID37255989
PMCPMC10225805
OpenAlexW3173187160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.