Evidence map›Paper›PMID 37255965›Full record

ArticlePhotoacoustics2023

Longitudinal volumetric assessment of inflammatory arthritis via photoacoustic imaging and Doppler ultrasound imaging.

Xiaorui Peng, Zhanpeng Xu, Aaron Dentinger, Shivangi Kewalramani, Janggun Jo, Guan Xu, David Chamberland, Nada Abdulaziz, Girish Gandikota, David Mills and 1 more

Open access · goldAbstract read
In one paragraph

Article in Photoacoustics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiaorui PengDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Zhanpeng XuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Aaron DentingerGeneral Electric Research, Niskayuna, NY, USA.
Shivangi KewalramaniDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Janggun JoDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Guan XuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
David ChamberlandDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Nada AbdulazizDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Girish GandikotaDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
David MillsGeneral Electric Research, Niskayuna, NY, USA.
Xueding WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
University of Michigan · USGeneral Electric (United States) · US

Funding

Physiology of Inflammatory Arthritis in High ResolutionR01AR060350 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, XUEDING · 2011 to 2021
$6.0M
NIAMS NIH HHS R01 AR060350
6 · The paper itself

Abstract

Aiming at clinical translation, we developed an automatic 3D imaging system combining the emerging photoacoustic imaging with conventional Doppler ultrasound for detecting inflammatory arthritis. This system was built with a GE HealthCare (GEHC) Vivid™ E95 ultrasound system and a Universal Robot UR3 robotic arm. In this work, the performance of this system was examined with a longitudinal study utilizing a clinically relevant adjuvant induced arthritis (AIA) murine model. After adjuvant injection, daily imaging of the rat ankle joints was conducted until joint inflammation was obvious based on visual inspection. Processed imaging results and statistical analyses indicated that both the hyperemia (enhanced blood volume) detected by photoacoustic imaging and the enhanced blood flow detected by Doppler ultrasound reflected the progress of joint inflammation. However, photoacoustic imaging, by leveraging the highly sensitive optical contrast, detected inflammation earlier than Doppler ultrasound, and also showed changes that are more statistically significant. This side-by-side comparison between photoacoustic imaging and Doppler ultrasound using the same commercial grade GEHC ultrasound machine demonstrates the advantage and potential value of the emerging photoacoustic imaging for rheumatology clinical care of arthritis.

Indexed as

Doppler ultrasound imagingEarly diagnosisPhotoacoustic imagingRheumatoid arthritisThree-dimensional imaging

Identifiers

PMID37255965
PMCPMC10225933
OpenAlexW4377194502

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.