Evidence map›Paper›PMID 37255782›Full record

ArticleJournal of diabetes and metabolic disorders2023

Pharmacokinetic assessment of cefpodoxime proxetil in diabetic rats.

Garima Mittal, Priyanka Jakhar, Anasuya Patel, Deepak Prabhakar Bhagwat

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes and metabolic disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Garima MittalDepartment of Pharmacy, Panipat Institute of Engineering and Technology, Panipat, Haryana India.ORCID 0000-0002-1781-6482
Priyanka JakharAmar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Ropar, Punjab India.
Anasuya PatelWockhardt Research Centre, Chikalthana, Aurangabad, Maharashtra India.
Deepak Prabhakar BhagwatDepartment of Pharmacy, Panipat Institute of Engineering and Technology, Panipat, Haryana India.
Govind Ballabh Pant University of Agriculture and Technology · INVeer Kunwar Singh University · INWockhardt (India) · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: In diabetes, multi-organ level dysfunction arising from metabolic complications is reported to influence the pharmacokinetics (PK) profile of many drugs. Hence, the present study was planned in rats to evaluate the effect of diabetes on the PK profile of cefpodoxime, a widely prescribed oral antibiotic. Method: PK profile of cefpodoxime was assessed after oral administration of cefpodoxime proxetil (10 and 20 mg/kg) and intravenous ( Result: In diabetic rats, there was significant ( Conclusion: The plasma exposure of cefpodoxime, a renally eliminated drug was significantly lowered in diabetic rats due to enhanced glomerular filtration. However, this observation needs to be confirmed through well controlled clinical trials.

Indexed as

Cefpodoxime ProxetilCreatinineDiabetes mellitusGlucose metabolic disorderPharmacokineticsProtein bindingStreptozotocin

Identifiers

PMID37255782
PMCPMC10225406
OpenAlexW4309714116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.