Evidence map›Paper›PMID 37255532›Full record

ArticleHIV/AIDS (Auckland, N.Z.)2023

Describing Engagement in the HIV Care Cascade: A Methodological Study.

Diya Jhuti, Gohar Zakaryan, Hussein El-Kechen, Nadia Rehman, Mark Youssef, Cristian Garcia, Vaibhav Arora, Babalwa Zani, Alvin Leenus, Michael Wu and 2 more

Abstract read
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In one paragraph

Article in HIV/AIDS (Auckland, N.Z.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Diya JhutiFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-4209-8769
Gohar ZakaryanFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-9907-2810
Hussein El-KechenDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Nadia RehmanDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Mark YoussefFaculty of Medicine, University of Toronto, Toronto, ON, Canada.
Cristian GarciaFaculty of Medicine, University of Toronto, Toronto, ON, Canada.
Vaibhav AroraFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Babalwa ZaniPublic Health Research Unit, AB Consulting, Cape Town, South Africa.
Alvin LeenusFaculty of Law, University of Ottawa, Ottawa, ON, Canada.
Michael WuMichael DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Oluwatoni MakanjuolaFaculty of Science, McMaster University, Hamilton, ON, Canada.
Lawrence MbuagbawDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Engagement in the HIV care cascade is required for people living with HIV (PLWH) to achieve an undetectable viral load. However, varying definitions of engagement exist, contributing to heterogeneity in research regarding how many individuals are actively participating and benefitting from care. A standardized definition is needed to enhance comparability and pooling of data from engagement studies. Objectives: The objective of this paper was to describe the various definitions for engagement used in HIV clinical trials. Methods: Articles were retrieved from CASCADE, a database of 298 clinical trials conducted to improve the HIV care cascade (https://hivcarecascade.com/), curated by income level, vulnerable population, who delivered the intervention, the setting in which it was delivered, the intervention type, and the level of pragmatism of the intervention. Studies with engagement listed as an outcome were selected from this database. Results: 13 studies were eligible, of which five did not provide an explicit definition for engagement. The remaining studies used one or more of the following: appointment adherence (n=6), laboratory testing (n=2), adherence to antiretroviral therapy (n=2), time specification (n=5), intervention adherence (n=5), and quality of interaction (n=1). Conclusion: This paper highlights the existing diversity in definitions for engagement in the HIV care cascade and categorize these definitions into appointment adherence, laboratory testing, adherence to antiretroviral therapy, time specification, intervention adherence, and quality of interaction. We recommend consensus on how to describe and measure engagement.

Indexed as

adherenceantiretroviral therapycascadeengagementHIVretention

Identifiers

PMID37255532
PMCPMC10226482

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.