Evidence map›Paper›PMID 37255480›Full record

ArticleJournal of bacteriology2023

Staphylococcus aureus SigS Induces Expression of a Regulatory Protein Pair That Modulates Its mRNA Stability.

Amer Al Ali, Jamilah Alsulami, Joseph I Aubee, Ayotimofe Idowu, Brooke R Tomlinson, Emily A Felton, Jessica K Jackson, Sarah J Kennedy, Nathanial J Torres, Lindsey N Shaw and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. SroA links SigS-dependent stress signaling to metabolic remodeling inbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Physiological Roles of anbioRxiv : the preprint server for biology · 2024
    Article
  4. Pathogens and global health · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Amer Al AliDepartment of Microbiology, College of Medicine, Howard University, Washington, DC, USA.
Jamilah AlsulamiDepartment of Microbiology, College of Medicine, Howard University, Washington, DC, USA.
Joseph I AubeeDepartment of Microbiology, College of Medicine, Howard University, Washington, DC, USA.
Ayotimofe IdowuDepartment of Biology, College of Arts and Sciences, Howard University, Washington, DC, USA.
Brooke R TomlinsonDepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida, USA.ORCID 0000-0001-6561-7931
Emily A FeltonDepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida, USA.
Jessica K JacksonDepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida, USA.
Sarah J KennedyDepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida, USA.
Nathanial J TorresDepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida, USA.
Lindsey N ShawDepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida, USA.ORCID 0000-0002-0629-8990
Karl M ThompsonDepartment of Microbiology, College of Medicine, Howard University, Washington, DC, USA.ORCID 0000-0001-6182-9507
University of South Florida · USHoward University · US

Funding

Sleep Disorders in Adults with Sickle Cell Disease: Frequency, Associations with Cardiovascular and Pain Indicators, and Responses to TreatmentU54MD007597 · NIMHD · HOWARD UNIVERSITY · PI William M. Southerland · 2019 to 2026
$37.7M
The Role and Regulation of Extracellular Proteases in Staphylococcus aureusR01AI124458 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SHAW, LINDSEY NEIL · 2017 to 2020
$1.7M
Dissecting the Influence of a C-Terminal Processing Protease on S. aureus PathogenesisR01AI157506 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SHAW, LINDSEY NEIL · 2021 to 2024
$1.5M
NIAID NIH HHS R01 AI124458NIAID NIH HHS R01 AI157506NIMHD NIH HHS U54 MD007597
6 · The paper itself

Abstract

SigS is the sole extracytoplasmic function sigma factor in Staphylococcus aureus and is necessary for virulence, immune evasion, and adaptation to toxic chemicals and environmental stressors. Despite the contribution of SigS to a myriad of critical phenotypes, the downstream effectors of SigS-dependent pathogenesis, immune evasion, and stress adaptation remain elusive. To address this knowledge gap, we analyzed the S. aureus transcriptome following transient overexpression of SigS. We identified a bicistronic transcript, upregulated 1,000-fold, containing two midsized genes, each containing single domains of unknown function (DUFs). We renamed these genes

Indexed as

Staphylococcal InfectionsStaphylococcus aureusAnimalsBacterial ProteinsGene Expression Regulation, BacterialMiceRNA StabilitySigma FactorTranscription FactorsBacterial ProteinsSigma FactorTranscription Factorsdomain of unknown functionECFextracytoplasmic function sigma factormRNAmRNA stabilitysigma factorsSigSStaphylococcus aureus

Identifiers

PMID37255480
PMCPMC10294688
OpenAlexW4378782934

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.