Evidence map›Paper›PMID 37254960›Full record

ArticleHuman brain mapping2023

Whole-brain analyses indicate the impairment of posterior integration and thalamo-frontotemporal broadcasting in disorders of consciousness.

Rajanikant Panda, Ane López-González, Matthieu Gilson, Olivia Gosseries, Aurore Thibaut, Gianluca Frasso, Benedetta Cecconi, Anira Escrichs, Coma Science Group Collaborators, Gustavo Deco and 3 more

Abstract read
In one paragraph

Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rajanikant PandaComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.ORCID 0000-0002-0960-4340
Ane López-GonzálezCenter for Brain and Cognition, Department of Information and Communication Technologies, Pompeu Fabra University, Barcelona, Spain.
Matthieu GilsonCenter for Brain and Cognition, Department of Information and Communication Technologies, Pompeu Fabra University, Barcelona, Spain.
Olivia GosseriesComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.
Aurore ThibautComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.
Gianluca FrassoWageningen Food Safety Research, Wageningen, The Netherlands.
Benedetta CecconiComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.
Anira EscrichsCenter for Brain and Cognition, Department of Information and Communication Technologies, Pompeu Fabra University, Barcelona, Spain.
Coma Science Group CollaboratorsComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.
Gustavo DecoCenter for Brain and Cognition, Department of Information and Communication Technologies, Pompeu Fabra University, Barcelona, Spain.
Steven LaureysComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.
Gorka Zamora-LópezCenter for Brain and Cognition, Department of Information and Communication Technologies, Pompeu Fabra University, Barcelona, Spain.
Jitka AnnenComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of the brain's dynamical activity is opening a window to help the clinical assessment of patients with disorders of consciousness. For example, glucose uptake and the dysfunctional spread of naturalistic and synthetic stimuli has proven useful to characterize hampered consciousness. However, understanding of the mechanisms behind loss of consciousness following brain injury is still missing. Here, we study the propagation of endogenous and in-silico exogenous perturbations in patients with disorders of consciousness, based upon directed and causal interactions estimated from resting-state fMRI data, fitted to a linear model of activity propagation. We found that patients with disorders of consciousness suffer decreased capacity for neural propagation and responsiveness to events, and that this can be related to severe reduction of glucose metabolism as measured with [

Indexed as

ConsciousnessConsciousness DisordersBrainBrain MappingFluorodeoxyglucose F18HumansMagnetic Resonance ImagingUnconsciousnessFluorodeoxyglucose F18broadcasting of informationdisorders of consciousnessin-silico exogenous perturbationsintegration of information

Identifiers

PMID37254960
PMCPMC10318246

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.