Evidence map›Paper›PMID 37254958›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR

Lamya H Al-Wahaibi, Anber F Mohammed, Fatema El-Zahraa S Abdel Rahman, Mostafa H Abdelrahman, Xuyuan Gu, Laurent Trembleau, Bahaa G M Youssif

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Lamya H Al-WahaibiDepartment of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Anber F MohammedPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Fatema El-Zahraa S Abdel RahmanDepartment of Basic Sciences, Faculty of Oral and Dental Medicine, Nahda University, Beni-Suef, Egypt.
Mostafa H AbdelrahmanPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Xuyuan GuSchool of Natural and Computing Sciences, University of Aberdeen, Aberdeen, UK.
Laurent TrembleauSchool of Natural and Computing Sciences, University of Aberdeen, Aberdeen, UK.
Bahaa G M YoussifPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Assiut University · EGUniversity of Aberdeen · GBAl-Azhar University · IDNahda University · EGPrincess Nourah bint Abdulrahman University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new series of indole-2-carboxamides

Indexed as

Antineoplastic AgentsLung NeoplasmsCell Line, TumorCell ProliferationDrug DesignDrug Screening Assays, AntitumorErbB ReceptorsErlotinib HydrochlorideHumansMolecular Docking SimulationMolecular StructureMutationProtein Kinase InhibitorsStaurosporineStructure-Activity RelationshipAntineoplastic AgentsEGFR protein, humanErbB ReceptorsErlotinib HydrochlorideProtein Kinase InhibitorsStaurosporineADMEantiproliferativeapoptosisEGFRIndolemutationresistance

Identifiers

PMID37254958
PMCPMC10234138
OpenAlexW4378781528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.