Evidence map›Paper›PMID 37254689›Full record

ArticleEmerging microbes & infections2023

Detection and phylogenetic analysis of highly pathogenic A/H5N1 avian influenza clade 2.3.4.4b virus in Chile, 2022.

Pedro Jimenez-Bluhm, Jurre Y Siegers, Shaoyuan Tan, Bridgett Sharp, Pamela Freiden, Magdalena Johow, Katherinne Orozco, Soledad Ruiz, Cecilia Baumberger, Pablo Galdames and 5 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pedro Jimenez-BluhmEscuela de Medicina Veterinaria, Facultad de Ciencias Biológicas, Facultad de Medicina y Facultad de Agronomía e Ingeniería Forestal, Pontificia Universidad Católica de Chile, Santiago, Chile.
Jurre Y SiegersVirology Unit, WHO H5 Regional Reference Laboratory, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
Shaoyuan TanDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Bridgett SharpDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Pamela FreidenDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Magdalena JohowServicio Agrícola y Ganadero (SAG), Santiago, Chile.
Katherinne OrozcoUnidad de Epidemiologia, Departamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
Soledad RuizEscuela de Medicina Veterinaria, Facultad de Ciencias Biológicas, Facultad de Medicina y Facultad de Agronomía e Ingeniería Forestal, Pontificia Universidad Católica de Chile, Santiago, Chile.
Cecilia BaumbergerUnidad de Epidemiologia, Departamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
Pablo GaldamesUnidad de Epidemiologia, Departamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
Maria Antonieta GonzalezUnidad de Epidemiologia, Departamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
Camila RojasUnidad de Epidemiologia, Departamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
Erik A KarlssonVirology Unit, WHO H5 Regional Reference Laboratory, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.ORCID 0000-0001-6004-5671
Christopher Hamilton-WestUnidad de Epidemiologia, Departamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.ORCID 0000-0002-5609-2237
Stacey Schultz-CherryDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Highly pathogenic avian influenza (HPAI) A/H5N1 viruses continue to pose a significant threat to animal and human health worldwide. In late 2022, the first confirmed case of HPAI A/H5N1 infection in wild birds in Chile near the Chilean-Peruvian border was reported. Active surveillance by our group in the adyacent Lluta river estuary revealed an increase in A/H5N1 prevalence coinciding with the arrival of migratory birds from the Northern Hemisphere. Genomic analysis of A/H5N1-positive samples demonstrated a close genetic relationship to strains detected in Peru during the same period, which originated from A/H5N1 viruses causing outbreaks in North America. Notably, we identified genetic mutations that did not correlate with known enhanced transmission or binding traits to mammalian receptors. In summary, this study provides valuable genomic insights into the A/H5N1 Clade 2.3.4.4b viruses in wild birds in Chile, emphasizing the need for enhanced surveillance and response strategies to mitigate the threat posed by these highly pathogenic avian influenza viruses in South America.

Indexed as

Influenza A virusInfluenza A Virus, H5N1 SubtypeInfluenza in BirdsAnimalsAnimals, WildBirdsChileMammalsPhylogenyAvian influenzaChileHPAIphylogenetic analysisSouth Americawild birds

Identifiers

PMID37254689
PMCPMC10283444

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.