Evidence map›Paper›PMID 37254594›Full record

ArticleBrain and behavior2023

Dopamine transporter binding in the brain is linked to irritable bowel syndrome in Parkinson's disease.

Kirsi Murtomäki, Juho Joutsa, Tuomas Mertsalmi, Elina Jaakkola, Elina Mäkinen, Reeta Levo, Mikael Eklund, Simo Nuuttila, Eero Pekkonen, Tommi Noponen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Increased frontal [NPJ Parkinson's disease · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kirsi MurtomäkiDepartment of Neurology, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0001-5759-1911
Juho JoutsaClinical Neurosciences, University of Turku, Turku, Finland.
Tuomas MertsalmiDepartment of Neurology, Helsinki University Hospital, Helsinki, Finland.
Elina JaakkolaClinical Neurosciences, University of Turku, Turku, Finland.ORCID 0000-0002-8003-1346
Elina MäkinenDepartment of Neurology, Helsinki University Hospital, Helsinki, Finland.
Reeta LevoDepartment of Neurology, Helsinki University Hospital, Helsinki, Finland.
Mikael EklundClinical Neurosciences, University of Turku, Turku, Finland.ORCID 0000-0002-1947-712X
Simo NuuttilaClinical Neurosciences, University of Turku, Turku, Finland.
Eero PekkonenDepartment of Neurology, Helsinki University Hospital, Helsinki, Finland.
Tommi NoponenDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Toni IhalainenClinical Physiology and Nuclear Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Valtteri KaasinenClinical Neurosciences, University of Turku, Turku, Finland.
Filip ScheperjansDepartment of Neurology, Helsinki University Hospital, Helsinki, Finland.
University of Helsinki · FIUniversity of Turku · FITurku University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastrointestinal symptoms are common in Parkinson's disease (PD), but their neurophysiological correlates are not well understood. We recently reported that functional gastrointestinal symptoms were not associated with asymmetry per se but might be associated with lower left striatal dopamine transporter (DAT) binding. The purpose of this study was to further investigate if specific gastrointestinal symptoms associate with monoamine transporter changes in specific striatal or extrastriatal areas.

methodsNinety PD patients, who underwent DAT ¹

resultsIrritable bowel syndrome (IBS) criteria were fulfilled in 17 patients and were linked to higher ¹

conclusionsThese findings suggest that PD patients with IBS may have higher DAT binding in the right hemisphere. This finding implicates alterations of brain neurotransmitter physiology in the gastrointestinal symptoms of PD patients.

Indexed as

Irritable Bowel SyndromeParkinson DiseaseBrainCorpus StriatumDopamine Plasma Membrane Transport ProteinsHumansSerotonin Plasma Membrane Transport ProteinsTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneDopamine Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport ProteinsTropanesdopamine transportergastrointestinal symptomsnonmotor symptomsParkinson's diseaseSPM

Identifiers

PMID37254594
PMCPMC10338780
OpenAlexW4378783594

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.