Evidence map›Paper›PMID 37254555›Full record

ArticlePsychological medicine2023

Resting-state network analysis of suicide attempt history in the UK Biobank.

Matthew F Thompson, Marjan Ghahramanlou-Holloway, Mikela A Murphy, Kanchana U Perera, Chelsie Benca-Bachman, Rohan H C Palmer, Joshua C Gray

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew F ThompsonDepartment of Medical & Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID 0000-0002-8268-7429
Marjan Ghahramanlou-HollowayDepartment of Medical & Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID 0000-0001-8377-3698
Mikela A MurphyDepartment of Medical & Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID 0000-0002-8688-0453
Kanchana U PereraDepartment of Medical & Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID 0000-0002-4542-8890
Chelsie Benca-BachmanBehavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, Atlanta, GA, USA.ORCID 0000-0002-5372-4593
Rohan H C PalmerBehavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, Atlanta, GA, USA.ORCID 0000-0002-6809-9962
Joshua C GrayDepartment of Medical & Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID 0000-0002-5351-561X

Funding

Integrative Prioritization of Alcohol and Drug-Addiction Related Genetic LociR01DA042742 · NIDA · EMORY UNIVERSITY · PI PALMER, ROHAN HUGH CRAIG · 2018 to 2022
$1.7M
Examining Suicide Risk from a Biopsychosocial Framework: A Large-Scale Cross-Sectional StudyF31MH129104 · NIMH · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI THOMPSON, MATTHEW · 2022 to 2022
$25k
NIDA NIH HHS R01 DA042742NIMH NIH HHS F31 MH129104
6 · The paper itself

Abstract

backgroundPrior research has identified altered brain structure and function in individuals at risk for self-directed violence thoughts and behaviors. However, these studies have largely utilized healthy controls and findings have been inconsistent. Thus, this study examined differences in resting-state functional network connectivity among individuals with lifetime suicide attempt(s)

methodsUsing data from the UK Biobank, this study utilized a series of linear regressions to compare individuals with lifetime suicide attempt(s) (

resultsThere were no significant between-group differences for between-network, within-network, or whole-brain functional connectivity after adjusting for age, sex, ethnicity, and body mass index and performing statistical corrections for multiple comparisons. Resting-state network measures may not differentiate between individuals with lifetime suicide attempt(s) and lifetime self-directed violence thoughts alone.

conclusionsNull findings diverge from results reported in smaller neuroimaging studies of suicide risk, but are consistent with null findings in other large-scale studies and meta-analyses. Strengths of the study include its large sample size and stringent control group. Future research on a wider array of imaging, genetic, and psychosocial risk factors can clarify relative contributions of individual and combined variables to suicide risk and inform scientific understanding of ideation-to-action framework.

Indexed as

Mental DisordersSuicide, AttemptedBiological Specimen BanksHumansSuicidal IdeationUK BiobankfMRIresting-stateself-directed violencesuicideUK Biobank

Identifiers

PMID37254555
PMCPMC11636966

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.