Evidence map›Paper›PMID 37254441›Full record

ReviewThe Journal of physiology2023

Motor potentials evoked by transcranial magnetic stimulation: interpreting a simple measure of a complex system.

Danny Adrian Spampinato, Jaime Ibanez, Lorenzo Rocchi, John Rothwell

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 3 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
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  5. Acute and post-acute neurobehavioral responses to lysergic acid diethylamide in healthy subjects: a randomized controlled study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  19. Recovery of Dexterous Motor Control via Non-Monosynaptic Corticospinal Pathways.medRxiv : the preprint server for health sciences · 2026
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Danny Adrian SpampinatoDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0001-8471-0859
Jaime IbanezDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0001-8439-151X
Lorenzo RocchiDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0003-3979-156X
John RothwellDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Fondazione Santa Lucia · ITUniversidad de Zaragoza · ESUniversity College London · GBUniversity of Cagliari · IT

Funding

Medical Research Council MR/P006671/1
6 · The paper itself

Abstract

Transcranial magnetic stimulation (TMS) is a non-invasive technique that is increasingly used to study the human brain. One of the principal outcome measures is the motor-evoked potential (MEP) elicited in a muscle following TMS over the primary motor cortex (M1), where it is used to estimate changes in corticospinal excitability. However, multiple elements play a role in MEP generation, so even apparently simple measures such as peak-to-peak amplitude have a complex interpretation. Here, we summarize what is currently known regarding the neural pathways and circuits that contribute to the MEP and discuss the factors that should be considered when interpreting MEP amplitude measured at rest in the context of motor processing and patients with neurological conditions. In the last part of this work, we also discuss how emerging technological approaches can be combined with TMS to improve our understanding of neural substrates that can influence MEPs. Overall, this review aims to highlight the capabilities and limitations of TMS that are important to recognize when attempting to disentangle sources that contribute to the physiological state-related changes in corticomotor excitability.

Indexed as

Motor CortexTranscranial Magnetic StimulationBrainElectromyographyEvoked Potentials, MotorHumansMuscle, Skeletalmotor cortexmotor-evoked potentialsmovementtranscranial magnetic stimulation

Identifiers

PMID37254441
PMCPMC10952180
OpenAlexW4378781452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.