ArticleGenome biology2023
Genomic and epigenomic determinants of heat stress-induced transcriptional memory in Arabidopsis.
Article in Genome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Acetylation as a dynamic regulatory interface between plant stress memory, cross-tolerance, and crop resilience design.Frontiers in plant science · 2026Pooled it
- Thermal priming enhances yield after recurrent heat stress and involves SlHSFA2-SlERFs in the regulation of transcriptional thermal memory in tomato.The Plant journal : for cell and molecular biology · 2026Article
- Unravelling Mechanisms of Acquired Drought Tolerance by Priming in Tomato Using Integrative Multi-Omics Phenotypic Analysis.Plant biotechnology journal · 2026Article
- Harnessing genomics approaches for heat stress resilience in wheat: from discovery to deployment.Journal of experimental botany · 2026Review
- Principles and mechanisms of plant acclimation to heat stress.Nature reviews. Molecular cell biology · 2026Review
- Dynamic reorganization of three-dimensional genome architecture during Populus diversification.Nature ecology & evolution · 2026Article
- Arabidopsis acclimation to daily environmental fluctuations converts a defense response regulator into a susceptibility factor toward Sclerotinia.The New phytologist · 2026Article
- Conserved heat shock factors HvHSFA2 and HvHSFA3 control barley heat stress memory through diverged mechanisms.Nature communications · 2025Article
- Exploring the mechanisms of desert plant adaptation to arid climates: a multi-omics analysis of dehydration and rehydration responses in Syntrichia caninervis.Stress biology · 2025Article
- Promoter and domain swap analysis delineates heat stress memory-specific determinants of heat shock factor HSFA2.Plant physiology · 2025Article
- Beware of Sealing Film of Petri Dishes!-Alters the Expression of a Large Number of Genes.International journal of molecular sciences · 2025Article
- Functions and Mechanisms of Histone Modifications in Plants.Annual review of plant biology · 2025Review
- Heat stress response and transposon control in plant shoot stem cells.Plant physiology · 2025Article
- Stress resilience in plants: the complex interplay between heat stress memory and resetting.The New phytologist · 2025Review
- BADDADAN: Mechanistic modelling of time-series gene module expression.Quantitative plant biology · 2025Article
- Establishment and Maintenance of Heat-Stress Memory in Plants.International journal of molecular sciences · 2024Review
- The heat shock factor 20-HSF4-cellulose synthase A2 module regulates heat stress tolerance in maize.The Plant cell · 2024Article
- Elevated Temperature Effects on Protein Turnover Dynamics inInternational journal of molecular sciences · 2024Article
- Inheritance of epigenetic transcriptional memory.Current opinion in genetics & development · 2024Review
- The Mediator kinase module enhances polymerase activity to regulate transcriptional memory after heat stress in Arabidopsis.The EMBO journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscriptional regulation is a key aspect of environmental stress responses. Heat stress induces transcriptional memory, i.e., sustained induction or enhanced re-induction of transcription, that allows plants to respond more efficiently to a recurrent HS. In light of more frequent temperature extremes due to climate change, improving heat tolerance in crop plants is an important breeding goal. However, not all heat stress-inducible genes show transcriptional memory, and it is unclear what distinguishes memory from non-memory genes. To address this issue and understand the genome and epigenome architecture of transcriptional memory after heat stress, we identify the global target genes of two key memory heat shock transcription factors, HSFA2 and HSFA3, using time course ChIP-seq.
resultsHSFA2 and HSFA3 show near identical binding patterns. In vitro and in vivo binding strength is highly correlated, indicating the importance of DNA sequence elements. In particular, genes with transcriptional memory are strongly enriched for a tripartite heat shock element, and are hallmarked by several features: low expression levels in the absence of heat stress, accessible chromatin environment, and heat stress-induced enrichment of H3K4 trimethylation. These results are confirmed by an orthogonal transcriptomic data set using both de novo clustering and an established definition of memory genes.
conclusionsOur findings provide an integrated view of HSF-dependent transcriptional memory and shed light on its sequence and chromatin determinants, enabling the prediction and engineering of genes with transcriptional memory behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.