Evidence map›Paper›PMID 37254111›Full record

ArticleCardiovascular diabetology2023

The impact of diabetes on the relationship of coronary artery disease and outcome: a study using multimodality imaging.

Matias Mäenpää, Iida Kujala, Esa Harjulahti, Iida Stenström, Wail Nammas, Juhani Knuuti, Antti Saraste, Teemu Maaniitty

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Matias MäenpääTurku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, 20521, Turku, Finland.
Iida KujalaTurku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, 20521, Turku, Finland.
Esa HarjulahtiTurku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, 20521, Turku, Finland.
Iida StenströmHeart Center, Turku University Hospital, Turku, Finland.
Wail NammasHeart Center, Turku University Hospital, Turku, Finland.
Juhani KnuutiTurku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, 20521, Turku, Finland.
Antti SarasteTurku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, 20521, Turku, Finland.
Teemu MaaniittyTurku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, 20521, Turku, Finland. teemu.maaniitty@utu.fi.
University of Turku · FITurku University Hospital · FITurku PET Centre · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with prediabetes or diabetes are at increased risk of developing cardiovascular disease and adverse outcomes. First-line coronary computed tomography angiography (CTA) followed by selective use of positron emission tomography (PET) myocardial perfusion imaging is a feasible strategy to diagnose and risk-stratify patients with suspected coronary artery disease (CAD). The aim of the present study was to study whether diabetes changes the relationship of CAD and long-term outcome.

methodsWe retrospectively identified consecutive symptomatic patients who underwent coronary CTA for suspected CAD. In patients with suspected obstructive CAD on CTA, myocardial ischemia was evaluated by

resultsA total of 1743 patients were included: 1214 (70%) non-diabetic, 259 (15%) prediabetic, and 270 (16%) type 2 diabetic patients. During 6.43 years of median follow-up, 164 adverse events occurred (106 deaths, 41 MIs, 17 UAPs). The prevalence of normal coronary arteries on CTA was highest in the non-diabetic patients (39%). The prevalence of hemodynamically significant CAD (abnormal perfusion) increased from 14% in non-diabetic patients to 20% in prediabetic and 27% in diabetic patients. The event rate was lowest in patients with normal coronary arteries and highest in patients with concomitant type 2 diabetes and hemodynamically significant CAD (annual event rate 0.2% vs. 4.7%). However, neither prediabetes nor diabetes were independent predictors of the composite adverse outcome after adjustment for the clinical risk factors and imaging findings.

conclusionsCoronary CTA followed by selective downstream use of PET myocardial perfusion imaging predicts long-term outcome similarly in non-diabetic and diabetic patients.

Indexed as

Coronary Artery DiseaseDiabetes Mellitus, Type 2Myocardial Perfusion ImagingPrediabetic StateComputed Tomography AngiographyCoronary AngiographyHumansMultidetector Computed TomographyPredictive Value of TestsRetrospective StudiesComputed tomography angiographyCoronary artery diseaseDiabetesHybrid imagingOutcomePerfusion

Identifiers

PMID37254111
PMCPMC10230727
OpenAlexW4378781343

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.