ArticleBMC pregnancy and childbirth2023
Association between serum progesterone levels on the day of frozen-thawed embryo transfer and pregnancy outcomes after artificial endometrial preparation.
Article in BMC pregnancy and childbirth, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Retrospective cohort study and meta-analysis of individualized luteal phase support with additional oral dydrogesterone in artificially prepared frozen embryo transfer cycles.Journal of assisted reproduction and genetics · 2025Pooled it
- Effects of vaginal vs oral progesterone supplementation before embryo transfer on live birth rates and levels: a randomized trial.Reproduction & fertility · 2025Trial
- Progesterone Levels on the Day of Frozen-thawed Embryo Transfer in Artificial Cycles with Vaginal Progesterone Do not Predict Clinical Pregnancy: a Prospective Study.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Pharmacodynamic interaction analysis of dydrogesterone, progesterone, and estradiol in combination-progestin HRT frozen embryo transfer: a prospective clinical cohort study.Reproductive biology and endocrinology : RB&E · 2026Article
- Serum progesterone and vaginal gel dose in artificial-cycle frozen embryo transfer: association with pregnancy outcome.Frontiers in endocrinology · 2026Article
- Elevated prolactin levels before endometrial transformation negatively impact reproductive outcomes in frozen embryo transfer cycles under hormone replacement therapy.BMC pregnancy and childbirth · 2025Article
- The Effect of Adding Daily 50 mg Intramuscular Progesterone to 800 mg Progesterone Suppository on TheInternational journal of fertility & sterility · 2024Article
- FSH/LH co-stimulation in Advanced Maternal Age (AMA) and hypo-responder patients - Arabian gulf delphi consensus group.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies have examined that a range of optimal serum P level during the implantation period was associated with optimal live birth rates. However, those results obtained with vaginal or intramuscular route of progesterone administration for luteal phase support (LPS) alone. Is there a relationship between the serum progesterone (P) on the day of frozen-thawed embryo transfer (FET) with the likelihood of a live birth (LB) in artificial cycles (AC) when using a combination of oral dydrogesterone and vaginal progesterone for LPS?
methodsThis was a retrospective study of 3659 FET cycles with artificial endometrial preparation in a Chinese tertiary-care academic medical centre from January 2015 to February 2017. Endometrial preparation was performed using estradiol (E
resultsThe LBRs according to the serum P quartiles were as follows: Q1: 35.7%; Q2: 37.4%; Q3: 39.1% and Q4: 38.9%. Logistic regression analysis showed that the odds of a LB were not significantly different between the low (P < 7.9 ng/mL) and high (P ≥ 7.9 ng/mL) progesterone groups before or after adjustment (crude OR = 0.89, 95% CI: 0.76-1.04; adjusted OR = 0.89, 95% CI: 0.75-1.04).
conclusionThe present study suggests that the serum P levels on the day of embryo transfer (ET) do not correlate with the likelihood of a LB in artificial cycles when using a combination of oral dydrogesterone and vaginal progesterone for luteal phase support.
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