Evidence map›Paper›PMID 37253986›Full record

Observational studyLung2023

Clinical Relevance of Staphylococcus aureus Nasal Colonization and Staphylococcal Enterotoxin-Specific IgE Sensitization in Late-Onset Asthma.

Ha-Kyeong Won, Youngsang Yoo, Jiwon Lee, Noeul Kang, Ji-Hyang Lee, Jun-Pyo Choi, Tae-Bum Kim, Sang-Heon Cho, Woo-Jung Song

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Lung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Ha-Kyeong WonDivision of Pulmonology and Allergy, Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.ORCID 0000-0001-8127-7885
Youngsang YooDepartment of Pulmonary, Allergy, and Critical Care Medicine, Gangneung Asan Hospital, Gangneung, Korea.ORCID 0000-0003-4582-2529
Jiwon LeeInstitute of Allergy and Clinical Immunology, Asan Medical Research Center, Seoul, Korea.ORCID 0009-0009-1584-2415
Noeul KangDivision of Allergy, Department of Medicine, Samsung Medical Center, Seoul, Korea.ORCID 0000-0003-0925-3891
Ji-Hyang LeeDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0003-4286-3114
Jun-Pyo ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0001-8925-1786
Tae-Bum KimDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0001-5663-0640
Sang-Heon ChoDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.ORCID 0000-0002-7644-6469
Woo-Jung SongDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. swj0126@amc.seoul.kr.ORCID 0000-0002-4630-9922
Ulsan College · KRGangneung Asan Hospital · KRSamsung Medical Center · KRSeoul National University · KRSeoul National University Bundang Hospital · KRVeterans Health Service Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This prospective observational study examined whether Staphylococcus aureus (SA) nasal colonization and staphylococcal enterotoxin (SE)-specific IgE sensitization synergistically affect clinical outcomes of adults with late-onset asthma (onset age ≥ 40 years). Nasal swabs were taken to evaluate SA colonization. Serum SE-IgE level was measured. Subjects were classified into 4 groups according to SA colonization and SE-IgE sensitization positivity. Among 181 patients with late-onset asthma recruited, the proportions of SA/SE (‒/‒), SA/SE (+ /‒), SA/SE (‒/ +), and SA/SE (+ / +) were 33.7%, 15.5%, 28.2%, and 22.6%, respectively. Severe asthma was more frequent in the SA/SE (+ / +) group than in the SA/SE (‒/‒) group (41.5% vs. 13.1%). The relationship of SA/SE (+ / +) with severe asthma was significant in multivariate logistic regression (vs. SA/SE (‒/‒); adjusted odds ratio: 4.36; 95% confidence intervals: 1.50‒12.73; p = 0.007), whereas SA/SE (+ /‒) or SA/SE (‒/ +) was not. In conclusion, SA nasal colonization and SE-IgE sensitization may synergistically affect disease severity in late-onset asthmatics.

Indexed as

AsthmaStaphylococcal InfectionsAdultClinical RelevanceEnterotoxinsHumansImmunoglobulin EStaphylococcus aureusEnterotoxinsImmunoglobulin EAsthmaEnterotoxinLate-onsetNasal colonizationStaphylococcus aureus

Identifiers

PMID37253986
OpenAlexW4378781466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.