Evidence map›Paper›PMID 37253884›Full record

SynthesisInternational journal of legal medicine2023

A small RNA, microRNA as a potential biomolecular marker to estimate post mortem interval in forensic science: a systematic review.

Roben Suhadi Pasaribu, Elza Ibrahim Auerkari, Antonius Winoto Suhartono, Pertti Auerkari

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of legal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Roben Suhadi PasaribuDivision of Forensic Odontology, Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia.
Elza Ibrahim AuerkariDivision of Forensic Odontology, Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia. eauerkari@yahoo.com.ORCID http://orcid.org/0000-0002-5680-7925
Antonius Winoto SuhartonoDivision of Forensic Odontology, Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia.
Pertti AuerkariDepartment of Mechanical Engineering, School of Engineering, Aalto University, Helsinki, Finland. pertti.auerkari@aalto.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-mortem interval (PMI) is the cornerstone of the forensic field to investigate. The examination technique by seeing the changes in the body such as algor mortis, rigor mortis, and livor mortis is a traditional technique in which accuracy is influenced by many factors. A biomolecular technique that uses microRNA (miRNA) biomarkers is developing because miRNA has good stability than other RNA, so it meets the requirements to be used for PMI estimation.

methodFollowing the PRISMA guidelines, journals were taken from 5 databases: Scopus, Science Direct, PubMed, Embase, and Springer. The review was carried out by two people. Inclusion criteria in this review are original research, published in the last 10 years, discussing miRNA as a biomarker for PMI estimation, and free full access. While exclusion criteria are not original research and not using English.

resultEighteen journals were reviewed in this study. The study was conducted using test animals (rats) and human samples with tissue sources taken from the liver, skeletal muscle, blood, bone, heart, skin, saliva, semen, brain, lung, vitreous humor, spleen, and kidney. miRNA expression levels after death showed different results based on miRNA target, tissue source, and others. DISCUSSION: The results of each study are different due to the use of different types of miRNA targets and tissue sources. miRNA has great potential to estimate PMI in forensic science, but it is necessary to control the influencing factors to obtain an accurate conclusion.

Indexed as

MicroRNAsAnimalsAutopsyBiomarkersForensic MedicineForensic SciencesHumansPostmortem ChangesRatsBiomarkersMicroRNAsBiomarkersmicroRNAsmiRNAPost-mortem changes

Identifiers

PMID37253884
PMCPMC10421780

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.