Evidence map›Paper›PMID 37253813›Full record

ArticleCommunications biology2023

Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation.

Angela Cabral, Julia Elise Cabral, Angelina Wang, Yiyang Zhang, Hailin Liang, Donya Nikbakht, Leslie Corona, Hal M Hoffman, Reginald McNulty

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Diverse Scaffolds Facilitate NLRP3 Clustering and Inflammasome Formation in Response to Perturbations in Cell Homeostasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. 8-Oxoguanine: A Lesion, an Epigenetic Mark, or a Molecular Signal?International journal of molecular sciences · 2025
    Review
  19. Sterile inflammation in laminopathies.European journal of cell biology · 2025
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Angela Cabral *Department of Molecular Biology and Biochemistry, University of California Irvine, Steinhaus Hall, Irvine, CA, 92694-3900, USA.ORCID http://orcid.org/0000-0003-1751-9311
Julia Elise Cabral *Department of Molecular Biology and Biochemistry, University of California Irvine, Steinhaus Hall, Irvine, CA, 92694-3900, USA.
Angelina WangDepartment of Molecular Biology and Biochemistry, University of California Irvine, Steinhaus Hall, Irvine, CA, 92694-3900, USA.ORCID http://orcid.org/0000-0003-2914-4246
Yiyang ZhangDepartment of Molecular Biology and Biochemistry, University of California Irvine, Steinhaus Hall, Irvine, CA, 92694-3900, USA.ORCID http://orcid.org/0000-0002-7201-1281
Hailin LiangDepartment of Molecular Biology and Biochemistry, University of California Irvine, Steinhaus Hall, Irvine, CA, 92694-3900, USA.ORCID http://orcid.org/0000-0001-6917-7048
Donya NikbakhtDepartment of Molecular Biology and Biochemistry, University of California Irvine, Steinhaus Hall, Irvine, CA, 92694-3900, USA.
Leslie CoronaDepartment of Molecular Biology and Biochemistry, University of California Irvine, Steinhaus Hall, Irvine, CA, 92694-3900, USA.
Hal M HoffmanDivision of Pediatric Allergy, Immunology, and Rheumatology, Rady Children's Hospital of San Diego, University of California, San Diego, San Diego, CA, USA.
Reginald McNultyDepartment of Molecular Biology and Biochemistry, University of California Irvine, Steinhaus Hall, Irvine, CA, 92694-3900, USA. rmcnulty@uci.edu.ORCID http://orcid.org/0000-0003-2101-1377
University of California, Irvine · USUniversity of California San Diego · US

Funding

Macromolecular assemblies of transcription factors initiated by pathogen infectionK22AI139444 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MCNULTY, REGINALD · 2019 to 2021
$297k
NIAID NIH HHS K22 AI139444NIAID NIH HHS L30 AI140191
6 · The paper itself

Abstract

The NLRP3 inflammasome is a key mediator of the innate immune response to sterile tissue injury and is involved in many chronic and acute diseases. Physically and chemically diverse agents activate the NLRP3 inflammasome. Here, we show that NLRP3 binds non-oxidized and Ox-mtDNA differentially, with a half maximum inhibitory concentration (IC

Indexed as

Clostridium acetobutylicumDNA GlycosylasesNLR Family, Pyrin Domain-Containing 3 ProteinDNA, MitochondrialHumansInflammasomesSignal TransductionDNA GlycosylasesDNA, MitochondrialInflammasomesNLR Family, Pyrin Domain-Containing 3 Protein

Identifiers

PMID37253813
PMCPMC10229695
OpenAlexW4378782426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.